Barrett's Esophagus Clinical Trials
A listing of Barrett's Esophagus medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
Found 349 clinical trials
TARGET-PBC: A 5-year Longitudinal Observational Study of Patients with Primary Biliary Cholangitis
You are being asked to be in this research study because you have PBC (primary biliary cholangitis) which is an uncommon chronic cholestatic liver disease characterized by progressive inflammation and destruction of the interlobular bile ducts, ultimately leading to the development of biliary cirrhosis.
Chronic insomnia and CSF markers of dementia
The purpose of this study is to identify the relationship between chronic sleep disturbance and chemicals in spinal fluid that are related to dementia and a molecule called orexin that helps regulate wakefulness and appetite in the brain. Individuals with sleep problems and good sleepers will be asked to participate.
Cardiometabolic Effects of Dipeptidyl Peptidase IV and Related Pathways
DPP4 is an enzyme that breaks down proteins that may affect blood sugar and the heart. We will recruit individuals from the Penn Biobank (cases, controls). Participants will be asked to complete a meal test, DXA, and echocardiogram with exercise. A cardiac MRI and related pilot study are optional.
High Velocity Nasal Insufflation (Hi-VNI) Use in Upper Airway Surgery
The goals of this study are to establish the efficacy of Hi-VNI in upper airway surgery from the anesthesiologists' and surgeons' perspectives, and to describe the ideal patient and the ideal pathology as well as suitable clinical scenarios when this oxygenation technique should be selected.
Discordance Between Capillary Refill Time and Oxygen Extraction Ratio in Septic Shock
In septic shock, restoring large-vessel (macrocirculatory) perfusion-reflected by a normal capillary refill time (CRT)-does not always mean that oxygen use at the tissue level has recovered. This mismatch, sometimes called loss of hemodynamic coherence, may be detectable by comparing CRT with the oxygen extraction ratio (O₂ER), a marker of how …
A Randomized Trial of Pessary in Singleton Pregnancies with a Short Cervix
Preterm birth is the primary driver of perinatal morbidity and mortality affecting approximately 11% of all newborns in the United States.1 Of the 4 million neonatal deaths that occur annually around the world, more than a quarter are the result of preterm birth.2 A short cervix by ultrasound has been …
IMAGING OF IN VIVO SIGMA-2 RECEPTOR EXPRESSION WITH [18F]ISO-1 POSITRON EMISSION TOMOGRAPHY (PET/CT) IN METASTATIC BREAST CANCER
Patients with metastatic breast cancer, that is biopsy proven or clinically documented by standard imaging (e.g. CT, MRI, Bone Scan, Ultrasound, FDG PET/CT), may be eligible for this study. Patients may participate in this study, if they are at least 18 years of age. We anticipate enrolling up to 30 …
SIMCAP (Surgery in Metastatic Carcinoma of Prostate): Phase 2.5 multi-institution randomized prospective clinical trial evaluating the impact of cytoreductive radical prostatectomy combined with best systemic therapy on oncologic and quality of life outcomes in men with newly diagnosed metastatic prostate cancer
This study investigates the effects of adding cytoreductive radical prostatectomy (CRP) to the standard treatment, best systemic therapy (BST), for metastatic prostate cancer (mPCa). CRP removes as much of the cancer as possible (and radical prostatectomy removes only prostate) while BST uses drugs toxic to cancer cells: chemotherapy and androgen …
A multi-center double-blind placebo-controlled Phase 4 study in patients with pulmonary arterial hypertension to assess the effect of selexipag on daily life physical activity and patients self-reported symptoms and their impacts
This is a prospective, multi-center, double-blind, randomized, placebo-controlled, parallel-group, exploratory Phase 4 study. The purpose is to identify the effect of selexipag on daily life physical activity assessed by a wearable device in patients with PAH (WHO Group 1). Approximately 100 patients will be enrolled in the study at 45 …
A Better FIT! Use of Medication to Improve Weight Loss in Suboptimal Early Responders to Behavioral Treatment
A 28-week research study is being conducted that is designed to help all participants lose weight. All participants will receive lifestyle modification (diet, exercise, and behavioral treatment). Participants who do not lose weight with lifestyle modification alone also will be prescribed an FDA-approved weight loss medication (phentermine) or placebo.
