Neoplasms Clinical Trials

A listing of Neoplasms medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 188 clinical trials
UPCC 03920: A Phase 1/1b Open-label Dose-escalation and Dose-expansion Study of TPST-1120 as a Single Agent or in Combination with Systemic Anti-Cancer Therapies in Subjects with Advanced Solid Tumors

Subjects may receive TPST-1120 alone or in combination with nivolumab. Subjects eligible to participate are those with advanced solid tumors.

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  • 19 Feb, 2024
  • 1 location
Early diagnosis of transthyretin cardiac amyloidosis

We would like to establish non-invasive methods using cardiac MRI and radionuclide imaging techniques (pyrophosphate technetium scan (PYP) to detect early stage CA infiltration in the heart.

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  • 19 Feb, 2024
  • 1 location
UPCC 02818: A Phase I/IB Study of Avelumab in Combination with Gemcitabine for Advanced Renal Cell Carcinoma with Sarcomatoid Differentiation

This study is being done because doctors are trying to develop better methods for treating kidney cancer that has spread to other organs in the body. This study will evaluate the initial safety and effectiveness of an investigational drug, avelumab, given in combination with a chemotherapy drug (gemcitabine) that is …

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  • 19 Feb, 2024
  • 1 location
UPCC 09118:A Phase 2 Study of Olaparib Monotherapy in Metastatic Breast Cancer Patients with Germline or Somatic Mutations in DNA Repair Genes (Olaparib Expanded)

This study will evaluate whether olaparib is effective in breast cancer patients whose tumor has a mutation in one of the other genes that function with BRCA1 and BRCA2 to repair damaged DNA.

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  • 19 Feb, 2024
  • 1 location
UPCC 28218: A Phase II Study of Nivolumab and Ipilimumab in Mucinous Colorectal and Appendiceal Tumors

This is a single-arm phase II study of twenty-one subjects with mucinous adenocarcinoma of the colon, rectum, or appendix with prior systemic therapy with a fluoropyrimidine, oxaliplatin, and irinotecan. Treatment will consist of nivolumab every 4 weeks and ipilimumab every 8 weeks until disease progression, unacceptable toxicity, or 2 years …

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  • 19 Feb, 2024
  • 1 location
PILOT STUDY EVALUATING THE UPTAKE OF [18F]F-GLN BY PET/CT IN BREAST CANCER

Up to 30 evaluable subjects will participate in a single imaging cohort. Patients will be stratified by breast cancer subtype with prioritization to recruit at least 10 estrogen-receptor-expressing (ER+) and 10 triple-negative breast cancers (TNBC).Patients who come to the University of Pennsylvania for diagnosis and/or treatment of breast cancer and …

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  • 19 Feb, 2024
  • 1 location
A pilot study evaluating in vivo PARP-1 expression with18F-FluorThanatrace positron emission tomography (PET/CT) in glioblastoma

Sub-Investigators in the oncology team will help to identify subjects for the imaging study. Patients may participate in this study if they are at least 22 years of age.

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  • 19 Feb, 2024
  • 1 location
Cancer detection rate of Abbreviated (Fast) Breast MRI (AB-MR) after negative Digitial Breast Tomosynthesis in Women status post Conservation Therapy (BCT)

Women treated for primary breast cancer who undergo breast conservation therapy face an increased risk of developing a second breast cancer in the ipsilateral and the contralateral breast.

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  • 19 Feb, 2024
  • 1 location
Evaluation of Vascular Health Profile in Predicting Venous Thromboembolism

The main goal of this study is to utilize previously validated cytometric markers of to identify cancer patients at high risk of VTE. The primary outcome will be DVT or pulmonary embolism (PE). Patients with pancreatic and brain cancer will be enrolled as these patients are known to have higher …

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  • 19 Feb, 2024
  • 1 location
UPCC 31216: Phase I/II Trial of Regorafenib Hydroxychloroquine and Entinostat in Metastatic Colorectal Cancer

The main purpose of this study is to find the best dose of hydroxychloroquine (HCQ) when given in combination with regorafenib and entinostat.

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  • 19 Feb, 2024
  • 1 location