Inflammation Clinical Trials

A listing of Inflammation medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 40 clinical trials
Targeting the Cholinergic Pathway in HIV-associated Inflammation and Cognitive Dysfunction

Although anti-retroviral therapy (ART) enhances life expectancy and overall quality of life (QoL), HIV-infected individuals are increasingly vulnerable to non-AIDS-related diseases including HIV-associated neurocognitive disorders (HAND). Inflammation is a primary mechanism in the pathogenesis of HAND and tobacco use may further exacerbate inflammation. Conversely, nicotine alone has anti-inflammatory effects suggesting …

  • 0 views
  • 19 Feb, 2024
  • 1 location
Measurement of Pulmonary Inflammation Using F-NOS Positron Emission Tomography (PET/CT) in E-cigarette Users

This is a 1 – 2 month study examining the extent of lung inflammation between e-cigarette smokers, cigarette smokers, and non-smokers using a new radio tracer, FNOS. FNOS is an experimental radio tracer used to look for inflammation in different parts of the body.

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  • 19 Feb, 2024
  • 1 location
Cardiovascular Inflammation Reduction Trial (CIRT): A randomized double-blind placebo controlled event-driven trial of weekly low-dose methotrexate (LDM) in the prevention of recurrent cardiovascular events among stable post-myocardial infarction patients with type 2 diabetes or metabolic syndrome

The combination of problems tends to occur together and raise your risk of heart disease and diabetes. Methotrexate is a drug commonly used to reduce inflammation (pain and swelling) in the joints of people with rheumatoid arthritis. It has been noticed that patients taking methotrexate for their arthritis seem to …

  • 0 views
  • 19 Feb, 2024
  • 1 location
Evaluation of in vivo Neuroinflammation Using 18F-NOS (PET/CT) in HIV Positive and Negative Subjects with Opioid Use Disorder and Healthy Controls

Study Purpose: The goal of this study is to learn more about how opiate use and HIV affects inflammation in the brain. We will study this using a type of Positron Emission Tomography (PET/CT) scan using a radioactive imaging drug called 18F-NOS that can be used to measure inflammation in …

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  • 19 Feb, 2024
  • 1 location
TARGET-PBC: A 5-year Longitudinal Observational Study of Patients with Primary Biliary Cholangitis

You are being asked to be in this research study because you have PBC (primary biliary cholangitis) which is an uncommon chronic cholestatic liver disease characterized by progressive inflammation and destruction of the interlobular bile ducts, ultimately leading to the development of biliary cirrhosis. 

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  • 19 Feb, 2024
  • 1 location
An International, Open Label, Randomised Controlled Trial Comparing Rituximab with Azathioprine as Maintenance Therapy in Relapsing ANCA-Associated Vasculitis  

Vasculitis is inflammation of blood vessels in your body. The exact cause is unknown, but we do know that it is an autoimmune condition. This means that your body’s own immune system, that normally fights infection, is overactive and is damaging your own blood vessels.

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  • 04 Dec, 2025
  • 1 location
Changes in Bone Quality Sarcopenia and Fat Distribution in HIV/HCV Patients after HCV Therapy

Understanding these associations in HIV+/HCV+ patients, how they differ from those of HCV+ and uninfected persons, and their relations with levels of inflammatory cytokines and insulin-like growth factor-1 (IGF-1) will shed light on the relations between HIV/HCV infections and musculoskeletal health, fat distribution, and the role of inflammation. It is …

  • 0 views
  • 19 Feb, 2024
  • 1 location
Molecular Imaging of the Underlying Mechanism of Cardiotoxicity in Patients with Light Chain Amyloidosis using Positron Emission Tomography (PET/CT)

In one cohort positron emission tomography/computed tomography (PET/CT) imaging will be used to measure inducible nitric oxide synthase (NOS) expression in the heart as a marker oxidative stress and inflammation using an investigational radiotracer called 18F-NOS. In the other cohort PET/CT imaging will be used to measure amyloid deposition as …

  • 0 views
  • 19 Feb, 2024
  • 1 location
Study to evaluate the safety and efficacy of Avacopan in subjects with moderate to severe hidraentis suppurativa

You are being invited to participate in a research study because you have hidradenitis suppurativa (HS), also called acne inversa. Avacopan is an investigational drug being studied to learn if it is safe and effective for the treatment for HS.

  • 0 views
  • 19 Feb, 2024
  • 1 location
Multimodal imaging outcome measures for ALS (Image ALS)

This research study is being done to learn more about changes over time in Positron Emission Tomography/Computed Tomography (PET/CT) imaging in people with amyotrophic lateral sclerosis (ALS).  We need data from people with ALS. If you agree to be in this study, you will have up to 6 PET/CT scans …

  • 0 views
  • 19 Feb, 2024
  • 1 location