Inflammation Clinical Trials

None

None

None

GENETICS MECHANISMS AND CLINICAL PHENOTYPES OF ARRHYTHMOGENIC CARDIOMYOPATHY

The well-established, consistent and precise phenotyping developed in the previous ARVC Registry (and published as the Modified Task Force Criteria), with a comprehensive primary genotyping approach, search for genetic modifiers, and biomarker analysis will fulfill the long-term goals of this proposal to identify the genetic basis of all forms of …

Vessel Wall Enhancement in Giant Cell Arteritis

The research study is being conducted to determine the utility of magnetic resonance imaging (MRI) in identifying inflammation of arteries supplying blood to the head, brain, and eyes, which may be useful in the diagnosis, prognosis, and treatment of giant cell arteritis (GCA; temporal arteritis).

Effects of Mu-opiate receptor engagement on the persistence of HIV-associated activation and viral reservoirs in individuals receiving medication assisted treatment for opioid use disorder

The primary objective of this proposal is to conduct a clinical study to establish whether chronic engagement of mu-opioid receptor (MOR) by full (methadone) or partial (buprenorphine + naloxone) agonists is a major factor in sustaining bacterial translocation and immune activation modulating in ART suppressed individuals with opioid use disorder …

The Role of the Microbiome in Inter-Individual Variability in NSAID Disposition and Response

Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used in the treatment of pain and inflammation. Mounting evidence indicates that rectal administration of NSAIDs is also effective in preventing pancreatitis following endoscopic retrograde cholangiopancreatography (ERCP) by an unknown mechanism.

Evaluation of in vivo Neuroinflammation in Parkinsons Disease Using 18F-NOS Positron Emission Tomography (PET/CT)

We will draw a 10 mL venous blood sample prior to injection that will be used to measure inflammatory cytokines and mitochondrial molecules implicated in inflammation. The results of these research tests will not be given to the subject, will not be included in the medical record and will not …

Study Evaluating the Safety and Efficacy of Itacitinib in Participants With Bronchiolitis Obliterans Syndrome Following Lung Transplantation

 Itacitinib works by blocking your body from producing substances called cytokines. Cytokines can cause inflammation that may contribute to your BOS. This is an open-label Study, which means that both you and your Study Doctor will know what Study Drug you are receiving.

Trauma Induced Coagulapathy and Inflammation

While a number of factors are known to be associated with the development of trauma induced coagulopathy (TIC), inflammation, and multi-organ failure, we currently cannot predict which patients are at risk for developing these life-threatening conditions with any certainty.