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Surgery Clinical Trials

A listing of Surgery medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Found 288 clinical trials

Featured trial
N Nichole Gallati

CAROTID REVASCULARIZATION AND MEDICAL MANAGEMENT FOR ASYMPTOMATIC CAROTID STENOSIS TRIAL (CREST-2) PROTOCOL

CREST-2 is a national multicenter stroke prevention study that is actively enrolling participants with narrowing in their carotid artery WITHOUT stroke or stroke warning signs (TIAs or mini-strokes). This study is comparing intensive medical management alone to intensive medical management used in combination with a procedure to remove plaque buildup …

35 years and older Non-Binary Phase N/A
Featured trial
P Penn Presbyterian Medical Center

A Phase 2 Multicenter, Double-blind, Randomized, Placebo-Controlled Trial to Evaluate Oral Ifetroban in Subjects with Symptomatic Aspirin Exacerbated Respiratory Disease (AERD)

The primary purpose of this study is to determine the therapeutic effectiveness of Ifetroban to improve sinus and nasal symptoms and quality of life in subjects with Aspirin Exacerbated Respiratory Disease (AERD).

18 years and older All Phase 2
Featured trial
S Sarah Leinwand

Inspire Upper Airway Stimulation System for Obstructive Sleep Apnea: Post Approval Study

Patients with Obstructive Sleep Apnea (OSA) who are interested in pursuing surgical treatment may be candidates for the Inspire device, an FDA-approved upper airway stimulation device that can help to treat OSA. This trial is collecting long-term safety and efficacy data in participants that are implanted with the Inspire device.

22 years and older All Phase 4
Featured trial
S Sarah Leinwand

A Six-Week Study of the Safety and Efficacy of JZP-110 in the Treatment of Excessive Sleepiness in Subjects with Obstructive Sleep Apnea (OSA)

Medication trial for the treatment of excessive sleepiness in adult subjects with treated or untreated obstructive sleep apnea (OSA).

18 years and older All Phase 3
Featured trial
K Kathleen O'Neill

Penn Uterine Transplantation for Uterine Factor Infertility (UNTIL) Trial

The UNTIL Trial is a new clinical research trial that offers uterine transplantation to women with uterine factor infertility (UFI). Participation in this trial requires going through an extensive selection process, creation of embryos through in vitro fertilization, and multiple surgeries. Study participants may remain in the study for 5-10 …

21-40 years Female Phase N/A
P Penn Presbyterian Medical Center

High Velocity Nasal Insufflation (Hi-VNI) Use in Upper Airway Surgery

The goals of this study are to establish the efficacy of Hi-VNI in upper airway surgery from the anesthesiologists' and surgeons' perspectives, and to describe the ideal patient and the ideal pathology as well as suitable clinical scenarios when this oxygenation technique should be selected.

99 years and younger All Phase N/A
P Penn Presbyterian Medical Center

CYTOSORB REDUCTION OF FREE HEMOGLOBIN/ACUTE KIDNEY INJURY (AKI) DURING CARDIAC SURGERY - REFRESH II

Reliance Agreement Request - Please refer to WIRB

99 years and younger All
J James Robinson

UPCC 07518: Pembrolizumab in combination with chemotherapy and image-guided surgery for malignant pleural mesothelioma (MPM).

The study is a single-arm phase I trial to evaluate the safety, feasibility, and preliminary efficacy of the addition of pembrolizumab and image-guided resection to surgical therapy and chemotherapy for MPM

18-99 years All Phase 1
P Penn Presbyterian Medical Center

CEA for the delineation of primary and recurrent tumor and metastases in patients undergoing curative surgery for colorectal cancer

SGM-101 is a fluorochrome-labeled anti-carcino-embryonic antigen (CEA) monoclonal antibody. What this means is that part of SGM-101 is a chemical that is attracted to and will attach to the cells of your cancer. Another part of SGM-101 is a chemical that will glow when infrared light is shined on it. …

99 years and younger All Phase 3
P Penn Presbyterian Medical Center

Study to Evaluate Imaging Feasibility, Safety and Diagnostic Performance Post Dosing of an Intraoperative Fluorescent Imaging Agent for Detection of Metastatic Lymph Nodes Primary Tumors and Tumor Margins in Patients with Solid Tumors

The purpose of this research study is to learn about the safety and effectiveness of using ONM 100 to obtain images of primary tumors and metastatic lymph nodes in patients with solid tumors undergoing routine surgery. Adults at least 18 years of age with a Biopsy-confirmed diagnosis of primary or …

18-99 years All Phase 2

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