Birth Defects Clinical Trials

Penn Uterine Transplantation for Uterine Factor Infertility (UNTIL) Trial

The UNTIL Trial is a new clinical research trial that offers uterine transplantation to women with uterine factor infertility (UFI). Participation in this trial requires going through an extensive selection process, creation of embryos through in vitro fertilization, and multiple surgeries. Study participants may remain in the study for 5-10 …

Promoting Recovery Optimization with WALKing Exercise after Stroke (PROWALKS)

The goal of this study is to improve walking ability after stroke. The interventions in this study will test whether combining fast walking training with a step activity monitoring program (FAST+SAM) is better in improving real-world walking activity compared to fast walking training alone (FAST) or a step activity monitoring …

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Psoriasis Specimen BioBank

Such a biobank will be critical to allowing us to deepen and expand existing collaborations between dermatology, rheumatology, immunology, and genetics to better define the genetic and immunological abnormalities in psoriatic disease and conduct studies that lead to personalized medicine approaches to diagnosis, staging, and treatment selection for this common …

FOLLOW-UP VESSEL WALL MR IMAGING TO EXPLORE SEX-DIFFERENCES OF INTRACRANIAL ARTERIAL WALL CHANGES AND INTRACRANIAL ATHEROSCLEROTIC PLAQUE TREATMENT EFFICACY

We propose a study to prospectively evaluate women and men with stroke using VWI to estimate the prevalence of vessel wall abnormalities leading to stroke. Early detection of vessel wall changes in correlation with modifiable risk factors will help us identify opportunities for early prevention of stroke in women.

UPCC 11917: A Dose-Finding Phase 1 Study of TAS-120 in Patients With Advanced Solid Tumors With or Without Fibroblast Growth Factor/Receptor (FGF/FGFR)-Related Abnormalities followed by a Phase 2 Study in Patients with Advanced Solid Tumors with FGF/FGFR-Related Abnormalities

Request for collaborative review: WIRB serving as IRB of record.

UPCC 03418: A Phase 1 First in Human Open Label Dose Escalation Study of AMV564 a CD33 x CD3 Tandem Diabody in Patients with Relapsed or Refractory Acute Myeloid Leukemia

Amphivena Therapeutics, Inc. (Amphivena) is studying an investigational drug called AMV564, which may help to treat acute myeloid leukemia (AML). The purpose of this clinical research study is to find the highest tolerable dose that can be given to patients with AML, and to recommend a dose to be used …

UPCC 13418: A Multicenter Open-Label Phase 1b Study to Assess Safety and Efficacy of Venetoclax in Combination with Gilteritinib in Subjects with Relapsed/Refractory Acute Myeloid Leukemia

The purposes of this study are to see if the study drugs, venetoclax and gilteritinib can be safely and effectively combined for the treatment of patients with acute myeloid leukemia (AML) that has returned after prior treatment, or has failed to respond to prior treatment and identify potential biomarkers.

Development of a reliable means for functional assessment of liver performance after Fontan operation: dual cholate clearance assay

In these populations, the assay may be able to predict more subtle or sub-clinical liver abnormalities that blood tests cannot detect. HepQuant® is a test that examines the ability of the liver to process a substance called cholate, which is a naturally occurring substance in the body.