Metastatic Cancer Clinical Trials

A study to evaluate an oral medication, Siponimod (BAF312), in patients with Secondary Progressive Multiple Sclerosis

The main purpose of the study is to see how effective and safe BAF312 is compared to a Placebo in patients with Secondary Progressive MS. A placebo is a “pill” (capsule or tablet) with no medicine inside. A placebo is used to make sure that the changes you report are …

Secondary Distribution of HIV Self-Tests: an Innovative Strategy for Promoting Partner Testing and Reducing Risk

CEA for the delineation of primary and recurrent tumor and metastases in patients undergoing curative surgery for colorectal cancer

SGM-101 is a fluorochrome-labeled anti-carcino-embryonic antigen (CEA) monoclonal antibody. What this means is that part of SGM-101 is a chemical that is attracted to and will attach to the cells of your cancer. Another part of SGM-101 is a chemical that will glow when infrared light is shined on it. …

An Open-label Single-arm Single-dose Prospective Multicenter Phase 2b Study to Establish Image Interpretation Criteria for 18F-Fluciclovine Positron Emission Tomography (PET) in Detecting Recurrent Brain Metastases after Radiation Therapy (PURSUE)

The purpose of this study is to take initial steps to address this area of diagnostic unmet need by defining image interpretation criteria for 18F-fluciclovine PET scans in detecting recurrent brain metastases in adults with suspected recurrence after radiation therapy.

METAMORPH

This is a cohort study of women with suspected or confirmed recurrent breast cancer, with accessible tumor by standard clinical biopsy, prior to starting a new therapy for recurrent metastatic disease. Study participants will be ascertained from the population of all persons greater than eighteen years of age receiving care …

A Study to Evaluate the Safety and Efficacy of Image Guided Surgery using Indocyanine Green for Intramolecular Imaging of Solid Tumors Compared to Standard of Care (TumorGlow) (PRIME)

The high rates of recurrence suggest that surgeons are unable to completely detect and remove primary tumor nodules in a satisfactory manner as well as lingering metastases in sentinel lymph nodes. There is some data to suggest that near infrared imaging can can improve on negative margins.

A Phase 2 Randomized Controlled Dose-titration Open-Label Study Evaluating the Safety and Efficacy of BIV201 in Addition to Standard of Care Compared to Standard of Care to Reduce the Recurrence of Ascites and Complications in Patients with Refractory Ascites Secondary to Decompensated Liver Cirrhosis

TBD

DEVELOPING ORAL LT3 THERAPY FOR HEART FAILURE (DOT3HF)

Parallel, Randomized, Double-Blind, Placebo-Controlled Crossover Clinical Trial The primary objective is to evaluate the safety of oral LT3 in heart failure with reduced ejection fraction (HFrEF) and heart failure with preserved ejection fraction (HFpEF) The secondary objective is to evaluate the feasibility and preliminary efficacy outcomes of oral LT3 therapy …

FES PET/CT in Endocrine Refractory Breast Cancer

  Positron emission tomography (PET/CT) imaging will be used to evaluate estrogen receptor (ER) activity, in sites of metastatic disease, using the investigational radiotracer [18F]fluoroestradiol (FES).  Imaging will occur prior to starting new therapy.

Padsevonil as adjunctive treatment of focal-onset seizures

The seizures can sometimes turn into generalized seizures, which affect the whole brain. This is called secondary generalization.