Metastatic Cancer Clinical Trials
A listing of Metastatic Cancer medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
Found 27 clinical trials
A phase II open-label study of ONC201 in adults with recurrent high-grade glioma
This is A phase II, open-label study of ONC201 in adults with recurrent high- grade glioma. Subjects will be age 18 or older with a histone H3 K27M mutant glioma that has progressed after radiation therapy. The primary objective is to estimate the overall response rate (ORR) of ONC201 in …
Clinical Transcriptomics in Systemic Vasculitis (CUTIS)
This study employs a multi-center approach to evaluate cutaneous vasculitis across several forms of idiopathic vasculitis. Patients with cutaneous manifestations of vasculitis will be evaluated by teams of primary vasculitis care providers and Dermatologists in order to facilitate optimal selection of patients and sampling of lesions. A punch skin biopsy …
(PREDICT) A Multi-Center Study in Patients Undergoing Anthracycline-Based Chemotherapy to Assess the Effectiveness of Using Biomarkers to Detect and Identify Cardiotoxicity and Describe Treatment
Over the past 2 decades, there has been a significant increase in life span of patients with cancer so that now, there are more than 10 million cancer survivors in the U.S. [1]. There is a growing recognition that although survival has improved, many long-term side effects including cardiac complications …
IMAGING OF IN VIVO SIGMA-2 RECEPTOR EXPRESSION WITH [18F]ISO-1 POSITRON EMISSION TOMOGRAPHY (PET/CT) IN METASTATIC BREAST CANCER
Patients with metastatic breast cancer, that is biopsy proven or clinically documented by standard imaging (e.g. CT, MRI, Bone Scan, Ultrasound, FDG PET/CT), may be eligible for this study. Patients may participate in this study, if they are at least 18 years of age. We anticipate enrolling up to 30 …
Intratumoral Gene Mediated Cytotoxic Immunotherapy (GMCI) For Resectable Non-Small Cell Lung Cancer
Surgery is the best treatment for patients with Stage I or II lung cancer; however, nearly 60% of patients have recurrence. Additional immunotherapeutic agents given before surgery may be greatly reduce recurrence. This is a Standard Phase I, 3+3 dose escalation trial designed to evaluate the safety and toxicity of …
Profiling and Perturbing the Human Immune System to Understand the Human Immune Network
This study aims to compare IBD patients with healthy controls to obtain a systems-level view of immune system perturbation by IBD. This intervention (anti-TNF therapy) will be intended to treat IBD but will also represent a major, broad immune system perturbation. Although the response of the patient in terms of …
Treatment for Mixed Urinary Incontinence: Mid-urethral Sling vs. Botox A
ABSTRACT Mixed urinary incontinence (MUI), defined as the presence of both stress urinary incontinence and urgency urinary incontinence, is a challenging condition for which clinicians frequently use multiple sequential treatments that have undergone limited head to head comparison in rigorous clinical trials. Mid-urethral Sling vs. Botox A (MUSA) is a …
The influence of nicotinic hepatic metabolism on neuroreceptor substrates of nicotine addiction
We will examine differences in nAChR availability based on individual differences in the nicotine metabolism rate. Work conducted by Dr. Lermans group at Penn, in collaboration with Drs. Rachel Tyndale (University of Toronto) and Neal Benowitz (University of California, San Francisco) has documented differences in smoking cessation and treatment response …
Medtronic Evaluation of Multi-Electrode Phased RF Technology in Persistent Atrial Fibrillation
The study is expected to be conducted at approximately 40 centers located in Europe, Canada and the United States to support US Food and Drug Administration (FDA) marketing application. A maximum of 350 subjects will be enrolled in the study to ensure 300 subjects can be evaluated for the primary …
Discordance Between Capillary Refill Time and Oxygen Extraction Ratio in Septic Shock
In septic shock, restoring large-vessel (macrocirculatory) perfusion-reflected by a normal capillary refill time (CRT)-does not always mean that oxygen use at the tissue level has recovered. This mismatch, sometimes called loss of hemodynamic coherence, may be detectable by comparing CRT with the oxygen extraction ratio (O₂ER), a marker of how …
