Breast Cancer Clinical Trials

A listing of Breast Cancer medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 74 clinical trials
PILOT STUDY EVALUATING THE UPTAKE OF [18F]F-GLN BY PET/CT IN BREAST CANCER

Up to 30 evaluable subjects will participate in a single imaging cohort. Patients will be stratified by breast cancer subtype with prioritization to recruit at least 10 estrogen-receptor-expressing (ER+) and 10 triple-negative breast cancers (TNBC).Patients who come to the University of Pennsylvania for diagnosis and/or treatment of breast cancer and …

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  • 19 Feb, 2024
  • 1 location
FES PET/CT in Endocrine Refractory Breast Cancer

  Patients may undergo primary tumor or metastatic biopsy, as part of their clinical care.  Patients may also be enrolled in a separate breast cancer biopsy protocol entitled “Metastatic Markers of Recurrent Tumor Phenotype for Breast Cancer” (METAMORPH).  We will ask permission to access tissue collected as part of clinical …

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  • 19 Feb, 2024
  • 2 locations
UPCC 03121: AURORA US: Prospective Biospecimen Repository in Metastatic Breast Cancer

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  • 19 Feb, 2024
  • 1 location
A Phase 2 Study of ZEN003694 in Combination with Talazoparib in Patients with Triple-Negative Breast Cancer

This study will test the experimental drug, ZEN003694, in combination with a marketed drug, talazoparib (Talzenna®), in patients with triple negative breast cancer (TNBC). Among the questions it will seek to answer are: 1. What are well-tolerated doses of ZEN003694 and talazoparib that can be given together without causing significant …

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  • 19 Feb, 2024
  • 1 location
Preoperative use of radiation boost to enhance effectiveness of immune checkpoint blockade therapy in operable breast cancer

Our study is a Phase 1Ib/2 clinical trial to evaluate the safety and feasibility of the combination of radiotherapy (RT) in a single fraction of 7 Gy with pembrolizumab in patients with operable breast cancer. We will employ a Simon Two Stage design to evaluate the safety, feasibility, and efficacy …

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  • 19 Feb, 2024
  • 1 location
A Pilot Study of Risk-Guided Cardioprotection with Carvedilol in Breast Cancer Patients Treated with Doxorubicin and/or Trastuzumab

Subjects with breast cancer starting treatment with anthracyclines/trastuzumab will be enrolled and their risk of cardiotoxicity calculated. If elevated risk, they will be randomized to intervention with carvedilol for 1 year vs usual care.

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  • 19 Feb, 2024
  • 1 location
A Phase 1/2 Study of Oral LOXO-292 in Patients

LOXO-292 is a highly potent and specific inhibitor of the RET RTK, with minimal inhibition of other kinase and non-kinase targets, and therefore may be of benefit to patients with tumors (such as NSCLC, MTC, PTC, and colon or breast carcinomas) that harbor RET alterations and/or depend on RET activation. …

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  • 19 Feb, 2024
  • 1 location
UPCC 01121 A Phase II Trial of Avelumab or Hydroxychloroquine with or without Palbociclib to Eliminate Dormant Breast Cancer (PALAVY)

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  • 19 Feb, 2024
  • 1 location
IMAGING OF IN VIVO SIGMA-2 RECEPTOR EXPRESSION WITH [18F]ISO-1 POSITRON EMISSION TOMOGRAPHY (PET/CT) IN METASTATIC BREAST CANCER

   Results of the standard breast cancer pathology immunohistochemistry (IHC) panel (usually estrogen receptor (ER), progesterone receptor (PgR) and HER2/neu) will be collected from the medical record for both metastatic breast cancer biopsy and primary breast cancer biopsy or surgery, when available.

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  • 19 Feb, 2024
  • 1 location
UPCC 04121 A Phase 1b/2 Study of the PARP Inhibitor Niraparib in Combination with Trastuzumab in Patients with Metastatic HER2+ Breast Cancer

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  • 19 Feb, 2024
  • 1 location