Depression Clinical Trials

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RECOVER: A PRospective Multi-cEnter Randomized Controlled Blinded Trial DemOnstrating the Safety and Effectiveness of VNS Therapy System as AdjunctivE Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression

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Investigating the Role of Slow-wave Activity as a Marker of Impaired Plasticity in Major Depressive Disorder

This research study aims to examine the role of sleep slow-wave activity (SWA) in modulating mood by testing the model that disrupting SWA during sleep can prevent homeostatic decreases in plasticity, thereby increasing plasticity and improving mood in individuals with MDD. Forty males and females with MDD (25-50 yo), and …

Trial to Evaluate the Efficacy, Safety, and Tolerability of Brexpiprazole as Adjunctive Therapy in the Maintenance Treatment of Adults With Major Depressive Disorder

You are being asked to take part in this study because you have been diagnosed with major depressive disorder (depression). Brexpiprazole is a medication being studied as a possible treatment for adjunctive treatment for Major Depressive Disorder (MDD).

An Open-Label Study to Assess the Long-term Safety and Efficacy of AXS-05 in Subjects with Major Depressive Disorder

This study is a multi-center, open-label trial to evaluate the long-term safety and efficacy of AXS-05 in subjects with major depressive disorder (MDD). Eligible subjects must have completed a prior MDD study with AXS-05 (AXS-05-301 or AXS-05-MDD-301) immediately prior to enrollment in this study.

A Phase 3 Multicenter Randomized Double-blind Placebo-controlled Trial to Evaluate the Efficacy Safety and Tolerability of Brexpiprazole as Adjunctive Therapy in the Maintenance Treatment of Adults With Major Depressive Disorder

This trial is a phase 3, double-blind, placebo-controlled, randomized withdrawal maintenance trial of brexpiprazole in subjects who require adjunctive treatment of MDD designed to fulfill a post-marketing commitment to the US Food and Drug Administration (FDA). There is a paucity of data on long-term use of the combination of ADT …

Novel neural circuit biomarkers of major depression response to computer-augmented CBT (1R01MH110939 - 01A1)

This is a trial of an FDA-approved treatment for Major Depressive Disorder (MDD), computer-augmented cognitive behavioral therapy (CCBT), to examine novel potential neural circuit biomarkers of treatment response rather than to test efficacy.

Using Natural Language Processing to Identify Depression in Patients with HIV

The purpose of this study is to develop algorithms that may help detect depressive symptoms in social media posts, specifically among men who have sex with men and who have HIV.

Effects of Insomnia Treatment on Metabolism in Patients with Depression

You may be eligible for one of our current research studies:Cognitive behavioral therapy for insomnia (CBT-I) has been the ‘gold standard’ for the treatment of insomnia. Insomnia and depression are highly related, and there’s a need for developing new treatments for depression. Previous research has indicated that, when a patient …

Software to Measure Consumer Preferences in the Treatment of Depression

The purpose of the study is to develop a new web-based software program to evaluate consumer preferences in the treatment of depression and, potentially, other disorders. We will also assess the stability of preference scores in this study.