Investigating the Role of Slow-wave Activity as a Marker of Impaired Plasticity in Major Depressive Disorder

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  • participants needed
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Updated on 19 February 2024

Summary

This research study aims to examine the role of sleep slow-wave activity (SWA) in modulating mood by testing the model that disrupting SWA during sleep can prevent homeostatic decreases in plasticity, thereby increasing plasticity and improving mood in individuals with MDD. Forty males and females with MDD (25-50 yo), and a group of twenty controls with no history of mood disorders will spend two nights in the laboratory: one baseline night of sleep, and one night where slow-wave sleep will be disrupted utilizing a validated procedure. Following each laboratory night, markers associated with net synaptic strength and plasticity will be assessed using several independent, but indirect indices including waking EEG theta power, metrics derived from transcranial magnetic stimulation, serum derived BDNF, and behavioral measures of learning and memory.

Description

If you agree to join the study, you will be asked to complete the following research procedures: You will first attend a 3 hour screening session. You and the study staff will discuss the study details and sign the consent form. You will then complete some questionnaires about your sleep, thoughts, and feelings. You will also have an interview that will include questions about your history of mental health symptoms. At this visit, you will also take a tour of lab where the TMS will take place. For 5 days prior to your in-lab stays, you will be asked to wear a wrist worn device which measures activity levels during the day and at night while completing a sleep diary each day. Visits 2 and 3 will be conducted at the Sleep Center located at the Hospital of the University of Pennsylvania.  You will be asked to arrive at the Sleep Center at 8pm. You will be asked to wear several sensors designed to measure sleep while also having an overnight sleep study. The following morning, you will have a blood sample taken, be provided with breakfast, complete computerized tasks and complete the TMS protocol. Afterwards you will be free to leave.  The second overnight will be the same as the first except auditory tones will be played throughout the night during SWS. In the morning you will follow the same procedures.
Your participation will last for approximately a month.

FAQ


Details
Condition Depression,healthy controls
Age 25years - 50years
Clinical Study Identifier04150718
Last Modified on19 February 2024

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