Congestive Heart Failure Clinical Trials

LIFE Study: Entresto TM in Advanced Heart Failure

This study aims to understand the benefits/risks of Entresto in NYHA III-IV patients.

REDUCE Study: For patients with Elevated Left Atrial Pressure with Heart Failure  

This study is assessing the safety and tolerability of an interatrial septal device implanted for those who have a dilated left atrium or some degree of diastolic dysfunction. This is often known as preserved ejection fraction heart failure. This study is blinded over the course of 2 years, and there …

Electrogram Guided Myocardial Advanced Phenotyping (EMAP) Study for patients recently diagnosed with cardiomyopathy

This study is enrolling newly diagnosed heart failure (within 6 months from diagnosis) patients with no known cause for their heart disease. We are utilizing already used technology, voltage mapping capabilities used in electrophysiology procedures, to more directly target weaker areas of the left and right ventricles. our physicians would …

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Acute Effects of Exogenous Ketone Ester Administration in Heart Failure

Please see section 1 of the full protocol

Skeletal Muscle Perfusion and Mitochondrial Function in Heart Failure with Preserved Ejection Fraction

The study is being conducted to understand why the skeletal muscle of patients with Heart Failure with Preserved Ejection Fraction (HFpEF) does not work as well as the muscle of individuals without heart failure. This study seeks to understand whether the problem is with blood and oxygen delivery to the …

EMPACT-MI: A streamlined multicentre randomised parallel group double-blind placebo-controlled superiority trial to evaluate the effect of Empagliflozin on hospitalisation for heart failure and mortality in patients with aCuTe Myocardial Infarction

TBD

AN EXPLORATORY OPEN-LABEL PROOF-OF-CONCEPT PHASE 2A STUDY OF MAVACAMTEN (MYK-461) IN PARTICIPANTS WITH HEART FAILURE WITH PRESERVED EJECTION FRACTION (HFpEF) AND CHRONIC ELEVATION OF CARDIAC TROPONIN I AND/OR NT-PROBNP

This is a multicenter, exploratory, open-label study to explore the efficacy and/or pharmacodynamic effect, PK, safety, and tolerability of mavacamten in approximately 35 ambulatory participants with symptomatic HFpEF and elevated cTnI and/or elevated NT-proBNP as defined in inclusion/exclusion criteria. The study will include an up to 7-week screening period (with …

Matching Perfusion and Metabolic Activity in HFpEF

This study will test whether Potassium Nitrate (KNO3), with and without Propionyl-L-Carnitine (PLC) and Nicotinamide Riboside (NR), improves submaximal exercise endurance and skeletal muscle oxidative phosphorylation capacity (SkM OxPhos) in participants with Heart Failure with Preserved Ejection Fraction (HFpEF). This study will also test whether the response to supplemental oxygen …