Found 706 clinical trials
EA8143: A Phase 3 RandOmized Study Comparing PERioperative Nivolumab vs. Observation in Patients with Localized Renal Cell Carcinoma Undergoing Nephrectomy (PROSPER RCC)
Request for collaborative review: CIRB serving as IRB of record.
A phase II open-label study of ONC201 in adults with recurrent high-grade glioma
This is A phase II, open-label study of ONC201 in adults with recurrent high- grade glioma. Subjects will be age 18 or older with a histone H3 K27M mutant glioma that has progressed after radiation therapy. The primary objective is to estimate the overall response rate (ORR) of ONC201 in …
An open-label multi-center roll-over study to assess long
The purpose is to evaluate the long-term safety of osilodrostat in patients who have already received osilodrostat treatment in a previous Novartis trial for treatment of Cushing's syndrome.
UPCC 07419: A Phase 1b/2a Multicenter Open-Label Dose Escalation Study to Determine the Maximum Tolerated Dose Assess the Safety Tolerability Pharmacokinetics and Efficacy Of Cc-220 Monotherapy and In Combination With Other Treatments In Subjects With Relapsed and Refractory Multiple Myeloma
The purpose of this study is to test the safety of an experimental drug CC-220, alone and in combination with other treatments. The study is also designed to define the appropriate dose for further testing of the study drug and these experimental combinations.
UPCC 45419: Phase I Study of Tasquinimod Alone and in Combination with Standard Therapy for Relapsed or Refractory Myeloma
The research study is being conducted to understand the effects of tasquinimod, an experimental medication, on patients with myeloma. Eligibile subject have multiple myeloma that has been previously treated and is now in need of additional treatment. Part 1 of this study evaluates tasquinimod alone. Part 2 of this study …
A Multi-Center Randomized Double-blind Placebo-controlled Dose-finding Study to Evaluate the Safety Tolerability Pharmacokinetics and Pharmacodynamics of CK-3773274 in Adults with Symptomatic Hypertrophic Cardiomyopathy and Left Ventricular Outflow Tract Obstruction
Please see section 1 of the full protocol
Substudy: Understanding COVID-19 vaccine responses in the setting of immunotherapy
Since its emergence, SARS-Cov2 has rapidly and widely spread across the globe due to lack of prior protective immunity in the human species. With widespread mitigation measures, all efforts focused on generating effective vaccination strategies that will provide herd immunity and protect the most vulnerable populations. However, there is very …
Treatment for Mixed Urinary Incontinence: Mid-urethral Sling vs. Botox A
ABSTRACT Mixed urinary incontinence (MUI), defined as the presence of both stress urinary incontinence and urgency urinary incontinence, is a challenging condition for which clinicians frequently use multiple sequential treatments that have undergone limited head to head comparison in rigorous clinical trials. Mid-urethral Sling vs. Botox A (MUSA) is a …
A Clinical Trial to Evaluate the Safety and Efficacy of Staged Bilateral Exablate Treatment of Medication Refractory Essential Tremor
The Exablate Model 4000 Type-1.0/1.1 Neuro system involves using an advanced, non-invasive technique currently approved by the Food and Drug Administration (FDA) to treat one side of your brain in a procedure called a thalamotomy (lesion the thalamus). This procedure involves performing an ablation (lesion) of an area of the …
A Phase 2 Dose Ranging Study to Evaluate the Efficacy and Safety of AMG 570 in Subjects with Active Systemic Lupus Erythematosus (SLE) with Inadequate Response to Standard of Care (SOC) Therapy
Modification #2 Feb 15, 2021: Title of protocol changed and phase changed from phase 2 to phase 2b. Changes in timing of selected activities, addition of labs (ESR, coagulation tests), the PRO sub-study and a COVID related consent for remote monitoring. IB updated to Edition 5. Modification #1 May 2020: …
