Found 706 clinical trials
An Open-Label Study to Assess the Long-term Safety and Efficacy of AXS-05 in Subjects with Major Depressive Disorder
This study is a multi-center, open-label trial to evaluate the long-term safety and efficacy of AXS-05 in subjects with major depressive disorder (MDD). Eligible subjects must have completed a prior MDD study with AXS-05 (AXS-05-301 or AXS-05-MDD-301) immediately prior to enrollment in this study.
To Serenade or To Sedate? That is Still The Question - A Followup Trial On Anxiolytic Options Before Peripheral Nerve Blocks
The research study is being conducted to determine if there are differences in anxiety scores, heart rate, blood pressure, and oxygen status when using sedation medication versus the patient's choice of listening to music while undergoing a peripheral nerve block before his or her surgery. The patient will either receive …
PRELIMINARY STUDY OF OPTICAL BIOMARKERS FOR NEURODEGENERATION IN CHRONIC CEREBROVASCULAR DISEASE
This research study will test whether a new optical device can reliably measure markers of blood flow and blood vessel function in the brain. We will be recruiting 60 subjects in total: 30 healthy, 15 with known narrowing of the carotid artery, and 15 small vessel stroke. All subjects will …
Evaluation of Corneal Confocal Microscopy in Ocular Surface Disease and/or Neuropathic Pain Patients
The purpose of this study is two-fold. Since there is currently no FDA approved software to analyze these images, the images taken will be used to help improve and refine current software, or help develop new software, in the hopes that it will be approved by the FDA. The images …
CYTOSORB REDUCTION OF FREE HEMOGLOBIN/ACUTE KIDNEY INJURY (AKI) DURING CARDIAC SURGERY - REFRESH II
Reliance Agreement Request - Please refer to WIRB
Effects of the Contraceptive Implant in Women with Sickle Cell Disease
This research is being done to see if women who have sickle cell disease (SCD) experience any difference in their pain while using a hormonal implant as compared to when not using a hormonal implant (Nexplanon). We are seeking women between the ages of 18 and 45 who have been …
Collection of bone marrow aspirate and biopsies for research
We want to study the effects of immune therapy for cancer on the normal immune system. Some of the cells of the immune system reside in the bone marrow, and can only be obtained by inserting a needle into the bone marrow (typically done through the back of the hip …
UPCC 19520: An Open-Label Multi-Institutional Pilot Study to Assess The Use of Glucarpidase in Adult Patients With Osteosarcoma Receiving High-Dose Methotrexate
This study is being done to answer the following question: Does scheduled glucarpidase reduce the levels of methotrexate in patients blood and lead to shorter hospitalizations and a reduction in toxicities? Eligible subjects will be those with osteosarcoma.
