Found 706 clinical trials
Software to Measure Consumer Preferences in the Treatment of Depression
The purpose of the study is to develop a new web-based software program to evaluate consumer preferences in the treatment of depression and, potentially, other disorders. We will also assess the stability of preference scores in this study.
Using Natural Language Processing to Identify Depression in Patients with HIV
The purpose of this study is to develop algorithms that may help detect depressive symptoms in social media posts, specifically among men who have sex with men and who have HIV.
Early longitudinal imaging in a Parkinsons Progression Markers Initiative (PPMI) satellite cohort
Please see protocol synopsis pages 8-15 in protocol
[18F]FLUOROPROPYL-TRIMETHOPRIM (F-TMP) PET/CT IMAGING TO EVALUATE BIODISTRIBUTION AND KINETICS IN HUMAN SUBJECTS
Patients with known or suspected bacterial infection at the time screening are eligible for this study. Patients may participate in this study if they are at least 18 years of age, and most participants will be receiving care at the clinical practices of the University of Pennsylvania. Up to 20 …
ALFAPUMP SYSTEM IN THE TREATMENT OF REFRACTORY OR RECURRENT ASCITES: A MULTICENTER SINGLE ARM WITHIN SUBJECT CROSSOVER DESIGN PIVOTAL STUDY
The POSEIDON study is a multi-center, prospective, single arm, crossover pivotal study enrolling up to 60 pivotal cohort patients and up to 30 additional Roll-in patients with refractory or recurrent ascites at up to 15 sites. Pivotal cohort patients will undergo a 3-month pre-implant observation phase after enrollment, followed by …
Vessel Wall Enhancement in Giant Cell Arteritis
The research study is being conducted to determine the utility of magnetic resonance imaging (MRI) in identifying inflammation of arteries supplying blood to the head, brain, and eyes, which may be useful in the diagnosis, prognosis, and treatment of giant cell arteritis (GCA; temporal arteritis). Study participants are eligible if …
CMT Subtype Biomarkers and Outcome Measures
In order to prepare for clinical trials for CMT, there is ongoing work to develop more sensitive outcome measures, and there is a need for complementary biomarkers, particularly target engagement measures that can be used in clinical trials for candidate therapies. Much of this work has been focused on CMT1A, …
Skeletal Muscle Perfusion and Mitochondrial Function in Heart Failure with Preserved Ejection Fraction
The study is being conducted to understand why the skeletal muscle of patients with Heart Failure with Preserved Ejection Fraction (HFpEF) does not work as well as the muscle of individuals without heart failure. This study seeks to understand whether the problem is with blood and oxygen delivery to the …
External Drainage of Thoracic Duct Lymph to Reduce Inflammatory Cytokines in Septic Shock Patients: A Pilot Trial with Concurrent Controls to Confirm Safety and Assess Preliminary Efficacy
This is an interventional cohort study (n=10) that will involve external drainage of thoracic duct lymph in Surgical ICU patients with septic shock. The lymph drainage will continue for up to a maximum of 7 days and will be continued in those patients discharged from ICU back to the ward …
