Found 706 clinical trials
University of Pennsylvania Centralized Observational Research Repository on Neurodegenerative Disease
The aim of this study is to create a repository of both cross-sectional and longitudinal data, imaging and biological specimens for neurodegenerative disease research.
A Phase 1 Open-Label Study to Evaluate the Safety Tolerability and Activity of AK002 in Patients with Eosinophilic Gastritis and/or Eosinophilic Gastroenteritis
This study is being done to see how safe the investigational new drug, AK002 is and how it affects your EG and/or EGE symptoms and the number of eosinophils in the stomach and the small intestine. This study will also be used to identify the best premedication and dose regimen …
Aerosol Biocontainment Device (ABCD) with Aerosol Clearance for Aerosol Generating Procedures
The primary goal of this study is to assess use of an aerosol biocontainment device for planned airway procedures under general anesthesia. This will serve as a platform for using this device as a novel biocontainment and aerosol evacuation system as part of rapid sequence intubation protocols for COVID-19 patients.
Trial of Best Available Therapy versus Autologous Hematopoietic Stem Cell Transplant for Treatment-Resistant Relapsing Multiple Sclerosis
The purpose of this study is to compare efficacy and safety of Autologous Hematopoietic Stem Cell Transplant (AHSCT) to best available therapy (BAT) in relapsing MS. Best available therapy is referring to the best available medications that are used to treat MS. Patients who agree to participate in the experimental …
Technology for Detection of SARS-Cov-2 in HIV-Positive Cancer Patients
The main purpose of this study is to try a new type of laboratory test for COVID-19 (also called SARS-CoV-2 or novel coronavirus). COVID-19 is a new disease, so not enough is known about it yet. This study hopes to collect more information about who is most as risk from …
Prospective 4D Computed Tomography Angiography Of The Bicuspid Aortic Valve Apparatus: A Comparison Of Bicuspid Aortic Valves With And Without Aortic Insufficiency
The purpose of this study is to characterize the differences in the aortic valve and aortic root anatomy in patients with BAVs in order to better understand the anatomical features that allow the BAV to function normally. With this information, surgeons and cardiologists will be better able to determine which …
A trial of transplanting Hepatitis C-viremic kidneys into Hepatitis C-Negative kidney recipients
The THINKER-NEXT research study is being done to determine whether it is safe to give a kidney transplant from a donor with hepatitis C to a patient without hepatitis C. The recipient will then be given a drug called Epclusa for 12 weeks to treat hepatitis C. Patients who are …
Glioblastoma adaptive global innovative learning environment
This research study aims to evaluate multiple investigational treatments for either newly diagnosed or recurrent brain tumors to determine if any of these study treatment(s) improve overall survival as compared to standard treatments. The investigational drugs that will be used in this research study are temozolomide for newly diagnosed glioblastoma …
High Velocity Nasal Insufflation (Hi-VNI) Use in Upper Airway Surgery
The goals of this study are to establish the efficacy of Hi-VNI in upper airway surgery from the anesthesiologists' and surgeons' perspectives, and to describe the ideal patient and the ideal pathology as well as suitable clinical scenarios when this oxygenation technique should be selected.
