Found 706 clinical trials
An open-label study to define the safety tolerability and clinical activity of deutetrabenazine (Austedo) in adult study subjects with dystonia
The purpose of this research study is to explore the safety and tolerability of the daily oral administration of deutetrabenazine, whose trade name is Austedo, in adults with dystonia.
Evaluation of SmartSleep Technology for Improving the Quality of Sleep in Healthy Adults
The purpose of this study is to learn more about how the SmartSleep technology affects cognitive performance of healthy adults undergoing conditions of chronic sleep restriction and emergency awakenings from sleep—two common conditions in spaceflight that pose challenges to astronauts’ performance. The study also aims to find the best SmartSleep …
Surgical Therapy for Obstructive Sleep Apnea on Blood Pressure & Peripheral Arterial Tonometry
The research study is being done to look at the effect of sleep apnea surgery on different measures ofcardiovascular (heart) function in people with obstructive sleep apnea.
A Randomized Placebo Surgery Controlled Double-blinded Multi-center Phase 2 Clinical Trial Evaluating Efcacy and Safety of VY-AADC02 in Advanced Parkinsons Disease with Motor Fluctuations
The main purpose of this study is to test the safety and efcacy (how well it works) of an experimental intervention called VY-AADC02 on the severity of PD. VY-AADC02 involves placing a gene in the brain that programs brain cells to produce an enzyme (protein) called AADC (aromatic amino acid …
Assessment of Chronic Lung Allograft Dysfunction Using Single-Breath & Multi-Breath Hyperpolarized Xenon 129 MRI
The research study is being conducted to determine the effectiveness of using hyperpolarized xenon-129 (HP 129-Xe) magnetic resonance imaging (MRI) in diagnosing and predicting the clinical course of patients who received lung transplantation.
Multimodal imaging outcome measures for ALS (Image ALS)
This research study is being done to learn more about changes over time in Positron Emission Tomography/Computed Tomography (PET/CT) imaging in people with amyotrophic lateral sclerosis (ALS). We need data from people with ALS. If you agree to be in this study, you will have up to 6 PET/CT scans …
General Pre-trial Screening Protocol for Enrollment of Volunteers into Research Protocols for Emerging Infections
Emerging infectious diseases are infections that have recently appeared within a population or those whose incidence or geographic range is rapidly increasing or threatens to increase in the near future. The main purpose of this screening protocol is facilitating the study of new emerging infections by collecting: 1. Some basic …
Universal COVID-19 Biobank: A subset of the Penn Medicine BioBank
The Universal COVID-19 Biobank – a component of the Penn Medicine Biobank – is collecting and storing biological specimens as well as information about people who may or may not have been exposed to the SARS-CoV-2 virus as well as those who have developed COVID-19 disease. This information will be …
Efficacy, Safety, and Tolerability Topical Nasal Spray in the Prevention of SARS-CoV-2 Infection in Healthcare Personnel
The purpose of this study is to assess the effectiveness, safety, and tolerability of GLS-1200 to prevent SARS-CoV-2 infection in healthcare personnel. GLS-1200 contains quinine diluted in saline (salt water). Pre-clinical studies have shown that quinine stimulates nasal cells to secrete compounds that may prevent growth of bacteria and reduce viruses …
Randomized Controlled Trial of Home Therapy with Caffeine Citrate in Moderately Preterm Infants with Apnea of Prematurity
This trial evaluates the effect of continuing treatment with caffeine citrate in the hospital and at home in moderately preterm infants with resolved apnea of prematurity on days of hospitalization after randomization. It is a randomized, double-blinded, placebo-controlled, multicenter trial. The primary outcome of the study will be the number …
