Found 706 clinical trials
Propranolol Rescue of Prolonged Labor
Over 30% of all cesarean deliveries (CD) performed in the United States are for prolonged labor. Current management strategies to resolve prolonged labor fail up to 50% of the time. The uterus is known to express beta receptors, which when stimulated, cause uterine relaxation. Accordingly, beta blockade has been shown …
18-Month Study With an Open-Label Extension Phase to Confirm Safety and Efficacy of BAN2401 in Subjects With Early Alzheimers Disease
BAN2401-G000-301 (Study 301) is an 18-month treatment (Core Study), multicenter, double-blind, placebo-controlled, parallel-group study in subjects with EAD (mild cognitive impairment [MCI] due to AD with intermediate likelihood/Prodromal AD or mild AD dementia) with confirmed amyloid pathology indicated by either positive amyloid load confirmed by amyloid PET assessment or CSF …
Kidney Disorders: Biological Specimen Repository and Clinical Database
To support the research of kidney disorders by creating a bank of biospecimens and a corresponding database of clinical information that will be used for future, unspecified research. Target population is adults with a kidney disorder, but the study also allows for enrollment of family members, healthy controls, and children. …
A Pilot Study of Network-Guided Transcranial Magnetic Stimulation for Adult ADHD
Attention Deficit Hyperactivity Disorder (ADHD) is characterized by symptoms of impulsivity, inattention, and hyperactivity that emerge in childhood and frequently persist into adulthood. These symptoms are accompanied by deficits in cognitive control and risky decision making that can lead to negative psychosocial and health-related outcomes. With advances in the neuroimaging …
Intraoperative molecular imaging of pulmonary nodules by BY SGM-101
Normal 0 false false false EN-US X-NONE X-NONE The research study is being conducted to determine if a new type of contrast agent can detect your cancer cells and to determine if the cancer has spread. The dye is unique for the following reasons: · It is not radioactive · …
Profiling and Perturbing the Human Immune System to Understand the Human Immune Network
This study aims to compare IBD patients with healthy controls to obtain a systems-level view of immune system perturbation by IBD. This intervention (anti-TNF therapy) will be intended to treat IBD but will also represent a major, broad immune system perturbation. Although the response of the patient in terms of …
MRI Assessment of Hip Fracture Risk and Therapy Response in HIV/HCV Coinfection
Project Summary Within a year of hip fracture 20-30% of patients die, and 50% percent lose the ability to walk. A consensus exists that infection with the human immunodeficiency virus (HIV) or the hepatis C virus (HCV) increases the likelihood of fracture risk. Co-infection with HIV and HCV is prevalent …
Cardiometabolic Effects of Dipeptidyl Peptidase IV and Related Pathways
DPP4 is an enzyme that breaks down proteins that may affect blood sugar and the heart. We will recruit individuals from the Penn Biobank (cases, controls). Participants will be asked to complete a meal test, DXA, and echocardiogram with exercise. A cardiac MRI and related pilot study are optional.
A Study to Evaluate the Effects of Annovera and Tampon Co-Usage on the Pharmacokinetics of Segesterone Acetate and Ethinyl Estradiol
Normal 0 false false false EN-US X-NONE X-NONE This study involves research about Annovera, an FDA-approved contraceptive vaginal system. The Annovera vaginal system is a ring made of a silicone rubber, which is inserted into your vagina. Annovera contains 2 hormones. One is a progestin called segesterone acetate (SA) and …
Study Evaluating the Safety and Efficacy of Itacitinib in Participants With Bronchiolitis Obliterans Syndrome Following Lung Transplantation
Normal 0 false false false EN-US X-NONE X-NONE You are being invited to participate in a research study because you have Bronchiolitis Obliterans Syndrome. Bronchiolitis Obliterans Syndrome (BOS) is a long term (chronic) rejection process that can occur in the transplanted lungs. Itacitinib works by blocking your body from producing …
