Found 706 clinical trials
TapToSleep: Guided Behavioral Approaches for Insomnia in Older Adults
Do you often struggle to fall asleep at night? The University of Pennsylvania, in partnership with Advanced Medical Electronics, have developed a low-risk, non-pharmacologic intervention that can be implemented on mobile devices for the treatment of insomnia. The purpose of this study is to examine the effects of this smartphone-delivered behavioral …
EXPLORATORY PILOT STUDY TO DISCOVER GENES THAT RESTORE THE MOLECULAR CIRCADIAN RHYTHM
The main purpose of this study is to see if blood serum collected from healthy young volunteers has a different effect on biorhythms measured in cells in a glass dish than serum collected from healthy older volunteers.You are being invited to participate in a research study because you have been …
The Networks of Withdrawal (NOW) Study
The purpose of the study is to learn more about people’s experiences of smoking withdrawal when they are smoking as usual and when they are undergoing smoking abstinence (not smoking as they usually do). We are interested in how people’s moment-to-moment experiences of withdrawal might change or might stay the …
Use of Digital Tomosynthesis for Detection and Case Management of Scaphoid and Distal Radius Fractures: A Volume RAD Data Collection Study
The purpose of this prospective cohort study is to collect clinical data about both diagnostic and treatment information related to wrist injury obtained through the use of VolumeRAD, an X-ray feature that collects X-ray images in a single sweeping motion using a technique called digital tomosynthesis (DTS). This study will …
Study Evaluating the Efficacy of Synergo Radiofrequency-Induced Thermochemotherapy Effect (RITE) with Mitomycin C (Synergo RITE + MMC) in CIS Non-Muscle Invasive Bladder Cancer (NMIBC)
The objectives of the study are to determine the efficacy and safety of Synergo® RITE and mitomycin C (MMC) in the treatment of carcinoma in situ (CIS) non-muscle invasive bladder cancer in adult patients who didn't respond to 2 courses of treatment with Bacillus Calmette-Guérin (BCG) installations. The Synergo® system …
Prospective Clinical Study of Tri-planar TarsometatarsL (TMT) ArthrodesIs with Early Weight-Bearing after Lapiplasty Procedure
People may participate in this study if their study doctor has determined that they have a type of bunion that could benefit from a bunion correction procedure called the Lapiplasty Procedure. The purpose of this clinical study is to collect information on patients in need of bunion correction surgery that …
A Pilot Phase I Randomized Study to evaluate Innate Immune Activation predictors of sustained viral control in HIV-Infected Adults Undergoing a Brief Analytical Treatment Interruption after the administration of Pegylated Interferon Alpha 2b in Combination with Two Intravenous Broadly HIV-1 Neutralizing Antibodies 3BNC117 and 10-1074
Our pilot study will evaluate whether the activation of antiviral innate mechanisms by administration of Pegylated Interferon alpha 2b (peg-IFN-2b) when combined with two broadly neutralizing antibodies (3BNC117 and 10-1074) in HIV positive participants with well controlled viral replication can result in viral control in the absence of ART or …
An Open-Label Study to Evaluate the Safety and Tolerability of PCS499 for the treatment of Necrobiosis Lipoidica
The main purpose of this research study is to test the safety and tolerability of PCS499 when given to individuals at a dose of 300 mg, twice a day for 1 week followed by giving PCS499 to individuals at a dose of 900 mg, twice a day, for remaining treatment …
A phase 2b double-blind randomised 5-arm vehicle-controlled dose ranging trial to evaluate the efficacy and safety of twice daily topical applications of delgocitinib cream 1 3 8 20 mg/g for 8 weeks in adult subjects with mild to severe atopic dermatitis.
The purpose of this clinical trial is to test different strengths of a new trial medication, delgocitinib cream 1, 3, 8, and 20 mg/g, and to investigate how treatment with delgocitinib cream affects atopic dermatitis (a type of eczema). key eligibility include: Age 18 years and above. Diagnosis of AD …
UPCC 18518: A Phase 3 Open-Label Randomized Parallel Group Study to Evaluate the Efficacy and Safety of Intrapleural Administration of Adenovirus-Delivered Interferon Alpha-2b (rAd-IFN) in Combination with Celecoxib and Gemcitabine in Patients with Malignant Pleural Mesothelioma
The study is an open-label, randomized, parallel group study conducted in patients with histologically confirmed MPM of epithelioid or biphasic (predominantly [50%] epithelioid) histology who have failed a minimum of 1 treatment regimen and a maximum of 2 treatment regimens, 1 of which must have been an anti-folate and platinum …
