Found 706 clinical trials
Preoperative use of radiation boost to enhance effectiveness of immune checkpoint blockade therapy in operable breast cancer
Our study is a Phase 1Ib/2 clinical trial to evaluate the safety and feasibility of the combination of radiotherapy (RT) in a single fraction of 7 Gy with pembrolizumab in patients with operable breast cancer. We will employ a Simon Two Stage design to evaluate the safety, feasibility, and efficacy …
Deep Phenotyping of ANGPTL3 4 and 8 Human Knockouts
Subjects with unusual lipids in subjects with known or suspected genetic variants that may be associated with change in lipoprotein kinetics will have two-night, one-day inpatient stay in CHPS, during which they will undergo extensive evaluation of lipoprotein kinetics using stable isotope techniques, OFTT, and OGTT. Subjects will complete a …
A Phase 3 Multicenter Randomized Double-blind Placebo-controlled Trial to Evaluate the Efficacy Safety and Tolerability of Brexpiprazole as Adjunctive Therapy in the Maintenance Treatment of Adults With Major Depressive Disorder
This trial is a phase 3, double-blind, placebo-controlled, randomized withdrawal maintenance trial of brexpiprazole in subjects who require adjunctive treatment of MDD designed to fulfill a post-marketing commitment to the US Food and Drug Administration (FDA). There is a paucity of data on long-term use of the combination of ADT …
A Randomized Controled Trial of Transcutaneous Magnetic Stimulation of the Stellate Ganglion to Treat Ventricular Tachycardia Storm
Two arm, randomized controlled trial with sham therapy control arm to assess the efficacy of low-frequency trans-cutaneous magnetic stimulation of the autonomic nerves in the neck for patients with ventricular arrhythmia. Twenty two (22) subjects with a high burden of ventricular arrhythmia will be randomized to undergo 60-minutes of low …
A PHASE II RANDOMIZED TRIAL TO EVALUATE THE OPTIMAL DOSING OF FECAL MICROBIOTA TRANSPLANTATION USING THE PENN MICROBIOME THERAPY PRODUCTS FOR RECURRENT CLOSTRIDIUM DIFFICILE INFECTION
Please reference attached protocol document, section "Study Summary" located on pages 7,8,9
Shifts in the Gut Microbiome Following Dietary Modification in Irritable Bowel Syndrome
Patients with bloating associated with irritable bowel syndrome (IBS) will be invited to participate in the study. Study to investigate the role of bacteria in the gastrointestinal tract (gut microbiome) in various patients with IBS. The purpose of this study is to characterize the gut bacteria and their associated molecules …
Chronic insomnia and CSF markers of dementia - Phase 2
The longstanding view has been that insomnia, and other forms of sleep disturbance, emerge as a consequence of dementia and are the result of progressive neuronal damage. However, there is growing evidence that the direction of causation may go both ways, with sleep disturbance potentially increasing vulnerability to dementia. Longitudinal …
A prospective multi-center investigational study of IMMray
Brief Summary: PanFAM-1 is a clinical study for early detection of pancreatic cancer in high-risk groups. The goals of the study are to assess the performance and diagnostic accuracy of the IMMray™ PanCan-d test compared to standard-of-care imaging.
A cross-sectional population study of energy expenditure in rest and exercise
Obesity is strongly regulated by energy expenditure, but the variables regulating individual levels of energy expenditure in the human population remain unknown. This study examines the parameters regulating energy expenditure at rest and during exercise in healthy adults across the lifespan. Participants will fill out a questionnaire and provide blood, …
DEVELOPING ORAL LT3 THERAPY FOR HEART FAILURE (DOT3HF)
Parallel, Randomized, Double-Blind, Placebo-Controlled Crossover Clinical Trial The primary objective is to evaluate the safety of oral LT3 in heart failure with reduced ejection fraction (HFrEF) and heart failure with preserved ejection fraction (HFpEF) The secondary objective is to evaluate the feasibility and preliminary efficacy outcomes of oral LT3 therapy …
