Found 706 clinical trials
CAROTID REVASCULARIZATION AND MEDICAL MANAGEMENT FOR ASYMPTOMATIC CAROTID STENOSIS TRIAL (CREST-2) PROTOCOL
CREST-2 is a national multicenter stroke prevention study that is actively enrolling participants with narrowing in their carotid artery WITHOUT stroke or stroke warning signs (TIAs or mini-strokes). This study is comparing intensive medical management alone to intensive medical management used in combination with a procedure to remove plaque buildup …
The Neural Basis for Amyotrophic Lateral Sclerosis
The purpose of this study is to evaluate memory, language and cognitive difficulties in patients with ALS. ALS is a neurological disease that affects nerve cells (motor neurons) in the brain and spinal cord. This condition largely affects the muscles however there are some individuals who also experience other neurological …
MOXI: Males, Antioxidants, and Infertility
MOXI is a research study to examine whether antioxidants can improve abnormal semen parameters in couples with male-factor infertility. Eligible male participants will be randomized to either an antioxidant supplement or placebo for 3 months, followed by fertility treatment with ovarian stimulation and intrauterine insemination.
An Open-Label Pilot Study of Fundamental Modification of the Gut Microbiota in the Treatment of Refractory Crohn’s Disease (Holiday)
You are being asked to take part in this research study because you have Crohn’s disease and the medical treatments you have tried have not brought you to full remission (clinically and physically symptom-free).
Brain and behavioral effect of tobacco labeling and packaging on adolescents at risk for nicotine dependence
The University of Pennsylvania is conducting a study of brain responses to graphic health warnings. The study includes receiving cell phone messages for 4 weeks and two functional Magnetic Resonance Imaging (fMRI) scans of the brain. These scans are non-invasive and do not use X-ray. To be eligible to participate, …
Insights into Impaired Arm Motor Control on Bilateral and Unilateral Functional Activities after Injury: A Kinematic Study
This study is being performed to assess how certain chronic disabilities - stroke, UE amputation, SCI, CP - differ from healthy subjects in their ability to perform ADLs. By studying the kinematics of the respective cohort of study participants as they are assesed performing common ADLS, our research team aims …
Identifying accurate and cost-effective fidelity measurement methods for therapists using CBT
Our objective is to compare the accuracy, costs, and cost-effectiveness of three fidelity measurement methods to assess fidelity to cognitive-behavioral therapy for youth. We will randomize 135 therapists, trained in cognitive-behavioral therapy to 3 conditions: self-report, chart stimulated recall, and behavioral rehearsal. To calculate our outcomes of interest, each condition …
RISE (Research in Smoking Elimination)
The main purpose of this research study is to assess how quitting smoking affects memory and attention.
T-Cell Response to Vaccination
The purpose of this study is to see how your body responds to a vaccine and how your body forms a protective response after vaccination. In this study we will use the yellow fever vaccine, an FDA approved vaccine that is commonly given to people traveling to certain parts of …
A Randomized, Double-blind, Active-controlled Trial to Assess the Efficacy and Safety of AXS-05 Administered Orally to Subjects with Treatment Resistant Major Depressive Disorder
We are currently enrolling participants for a clinical research study to look at the effectiveness and safety of an investigational medication AXS-05 (a combination of bupropion and dextromethorphan) compared to bupropion (Approved by FDA), in patients with depression who have not responded to prior treatment with at least one antidepressant. …
