Found 706 clinical trials
Towards predicting the analgesic response to ibuprofen following third-molar extraction
NSAIDs like ibuprofen are pain relievers that are commonly used to reduce pain after dental procedures. Patients who have their impacted third molar teeth taken out usually experience pain one to three hours after surgery and require pain relievers for at least 2 days. Most people (about 70-90%) experience good …
Padsevonil as adjunctive treatment of focal-onset seizures
You are being asked to participate in this clinical research study because you have epilepsy associated with focal onset seizures (or sometimes called partial seizures), and your seizures are not well controlled with your current treatment. Seizures are caused by abnormal electrical disturbances in the brain. Focalonset seizures occur when …
A multi-center double-blind placebo-controlled Phase 4 study in patients with pulmonary arterial hypertension to assess the effect of selexipag on daily life physical activity and patients self-reported symptoms and their impacts
This is a prospective, multi-center, double-blind, randomized, placebo-controlled, parallel-group, exploratory Phase 4 study. The purpose is to identify the effect of selexipag on daily life physical activity assessed by a wearable device in patients with PAH (WHO Group 1). Approximately 100 patients will be enrolled in the study at 45 …
Non-Dipping Hypertension and The Human Chronobiome
The NDHTEN-Chronobiome study team will receive a request to deploy a 24h-ABPM. The study doctor's will make the results from the ambulatory blood pressure monitor (APBM) available to your physician. Measuring your blood pressure over the course of 24 hours will identify whether your blood pressure is lowering at night …
Open-Labeled Trial Of Zepatier For Treatment Of Hepatitis C-Negative Patients Who Receive Lung Transplants From Hepatitis C-Positive Donors
There has only been a modest increase in the number of lung transplants each year, increasing from a yearly average of 2,400 between 2009 and 2011, to 2,800 in 2016. Despite this, more than 300 patients died or became too sick to transplant on the lung transplant waiting list in …
Prospective Elimination Of Distal Coronary Sinus-Left Atrial Connections for Atrial Fibrillation Ablation Trial
Atrial fibrillation (AF) is the most common cardiac arrhythmia affecting millions of people in the US and around the world. Over the last 20 years, the catheter based AF ablation procedure has been widely adopted. However, the long-term success in paroxysmal AF is 50% and as low as 20% in …
A PHASE II STUDY EVALUATING THE EFFICACY AND SAFETY OF NIRAPARIB AND TUMOR-TREATING FIELDS IN RECURRENT GLIOBLASTOMA
Glioblastoma (GBM) is the most common primary malignant brain tumor in adults and is near uniformly fatal. Only three treatments have been approved by the US FDA for GBM in the past 2 decades: temozolomide, bevacizumab, and, most recently, tumor-treating fields (TTFields). TTFields represents a novel anti-cancer modality that creates …
Research Study of a Levonorgestrel 52 MG IUD for the treatment of heavy menstrual bleeding
Healthy women 18 to 50 years of age who are seeking treatment for heavy menstrual bleeding and do not wish to become pregnant during the next ten months are invited to participate.
FLExAbility Sensor Enabled Substrate Targeted Ablation for the Reduction of VT (LESS-VT) Study
Please see section1 of the full protocol
A study of human multi-sensory integration: A neurophysiologic correlate of conscious perception
This is a prospective dual parallel arm human subject study aimed at determining the relationship between level of sedation (consciousness) and features of multi and uni-sensory evoked potentials with the ultimate goal of developing novel means of detecting consciousness under anesthesia with potential for application to other clinical settings such …
