Found 706 clinical trials
Three Approaches to Maintenance Therapy for Chronic Insomnia in Older Adults (R01AG054521)
Medication is FDA approved. The present study is a further evaluation of the behavioral pharmacotherapeutic strategy (i.e., partial reinforcement following the obtention of treatment response with standard treatment) with a particular focus on 1) how low a dose may be used (dose = frequency of active medication) and 2) how …
A Phase 2 Randomized Placebo-Controlled Study of Safety and Efficacy Following Repeat-Dose Administration of Evinacumab (anti-ANGPTL3) in Patients with Severe Hypertriglyceridemia (sHTG) at Risk for Acute Pancreatitis
A phase 2, randomized, placebo-controlled study designed to evaluate the efficacy and safety of repeated doses of evinacumab in adult patients with severe hypertriglyceridemia. The study consists of screening period (up to 37 days), a baseline/single-blind placebo run in period, a 12-week double-blind treatment period, a single-blind 12 week treatment …
Trimethoprim-Sulfamethoxazole Effects on the Nasal Microbiome in Granulomatosis with Polyangiitis Study
Trimethoprim-sulfamethoxazole (TMP-SMX; Bactrim) is an FDA-approved drug for the treatment of infections and commonly used for 2 weeks or less. The purpose of this study is to observe the changes in the microbiome in your nose before, during, and after taking TMP-SMX for 4 weeks. The extended duration of TMP-SMX …
A Pilot Study of Risk-Guided Cardioprotection with Carvedilol in Breast Cancer Patients Treated with Doxorubicin and/or Trastuzumab
Subjects with breast cancer starting treatment with anthracyclines/trastuzumab will be enrolled and their risk of cardiotoxicity calculated. If elevated risk, they will be randomized to intervention with carvedilol for 1 year vs usual care. Low risk subjects will be usual care. All subjects will be followed with serial echo, survey, …
A single-arm open-label phase 2 study evaluating the efficacy and safety of abemaciclib in patients with recurrent oligodendroglioma
This is a single-center, phase II, single-arm, open label study evaluating the efficacy and safety of abemaciclib for patients with recurrent oligodendroglioma (molecularly defined per the WHO 2016 guidance, i.e., presence of IDH mutation and 1p19q codeletion). The study will enroll 10 subjects who are evaluable for the studys primary …
UPCC 07518: Pembrolizumab in combination with chemotherapy and image-guided surgery for malignant pleural mesothelioma (MPM).
The study is a single-arm phase I trial to evaluate the safety, feasibility, and preliminary efficacy of the addition of pembrolizumab and image-guided resection to surgical therapy and chemotherapy for MPM
Vessel Wall Magnetic Resonance Imaging to Explore Gender Differences of Intracranial Arterial Wall Changes After Suspected Stroke
Mortality related to cardiovascular disease in the US is improving. Yet the rate of decline is less for women than for men. Womens health is unique due to the varying reproductive stages, and differences are even greater due to gender-specific characteristics of the heart and vasculature. While women have some unique risk factors, …
SPYAL HTN-ON Med for Hypertension
You are being asked to take part in a clinical research study because your blood pressure (BP) is not adequately controlled with medications. Purpose of this study is to provide more information about a medical device intended to help treat high blood pressure in patients whose blood pressure is not …
Changing the Trajectory of Mild Cognitive Impairment with CPAP Treatment of Obstructive Sleep Apnea (Memories 2)
Are you having any trouble with your memory or sleep?This research study will explore whether treating sleep apnea can improve memory. Compensation is up to $300 for the participant's time and up to $100 for the study partner.
