Found 706 clinical trials
A Pilot Proof of Concept Single-Center Study of the Use of Oritavancin in Systemic Staphylococcus aureus Infections in Patients with Opioid Use Disorder
The study participants will be in the study for approximately 2 months including the screening, intervention phase and the 6 weeks of follow-up time
PERSPIRE: Preventing rehospitalization in lung transplant recipients through mHealth utilizing individualized rehabilitation prescriptions
Lung transplant recipients have the highest risk of readmission after the index admission among solid organ transplant patients. We hypothesize that targeted, individualized rehabilitation plans will reduce the risk of unplanned readmission in the first year after lung transplantation.To address this hypothesis, we will conduct a prospective cohort study of …
TRaCkLIGHT study for people with moderate to severe Crohn's Disease
Patients with moderate to severe Crohn's disease, who have failed prior treatment with the standard anti-TNF therapy will receive the study medication - MDGN-002 - which may help treat the Crohn's disease and relieve its symptoms.
Measurement of Pulmonary Inflammation Using F-NOS Positron Emission Tomography (PET/CT) in E-cigarette Users
This is a 1 – 2 month study examining the extent of lung inflammation between e-cigarette smokers, cigarette smokers, and non-smokers using a new radio tracer, FNOS. FNOS is an experimental radio tracer used to look for inflammation in different parts of the body. The tracer that we will be …
A Multicenter Randomized Double-Blind Placebo-Controlled 52-Week Maintenance and an Open-Label Extension Study of the Efficacy and Safety of Risankizumab in Subjects with Ulcerative Colitis Who Responded to Induction Treatment in M16-067 or M16-065
The study will enroll subjects who have completed Study M16-067 or Study M16-065 and have achieved clinical response, defined as decrease from Baseline of induction study of Adapted Mayo score greater than or equal to 2 points and greater than or equal to 30%, PLUS a decrease in rectal bleeding …
Comparing the effects of Oral Contraceptive Pills versus Metformin in the medical management of overweight/obese women with Polycystic Ovary Syndrome
OCPs increase the risk of MetS specifically by producing an atherogenic lipoprotein phenotype, increasing blood pressure and/ or body weight while metformin modestly decreases MetS risk by decreasing body weight and improving lipid phenotype. The combination of OCP and metformin (OCP, through lowering androgens, and metformin, through improvement in insulin …
Dapagliflozin Effect on symptoms and blomarkers in patients with Heart Failure (DEFINE-HF)
The purpose of this study is to find out if a drug called dapagliflozin would be effective in improving the blood tests and symptoms related to your heart failure.
Management of the Patent Ductus Arteriosus in Premature Infants Trial (PDA Trial)
This is a pragmatic randomized multicenter, effectiveness study comparing active treatment of a sPDA to expectant management. This trial estimates the risks and benefits of active treatment versus expectant management of a symptomatic patent ductus arteriosus (sPDA) in premature infants.
Integrated biomarker PET/CT imaging trial for assessing hypoxia in soft tissue sarcomas using a novel PET/CT tracer
This is a pilot study. Subjects with primary soft tissue sarcoma of the extremities may be eligible for this study. Subjects may participate in this study if they are at least 18 years of age. Most participants will be receiving care at the clinical practices of the University of Pennsylvania …
A Phase 1/2 Study of Oral LOXO-292 in Patients
LOXO-292 is a highly potent and specific inhibitor of the RET RTK, with minimal inhibition of other kinase and non-kinase targets, and therefore may be of benefit to patients with tumors (such as NSCLC, MTC, PTC, and colon or breast carcinomas) that harbor RET alterations and/or depend on RET activation. …
