Found 706 clinical trials
AN UN-BLINDED INTRA-PATIENT COMPARISON OF TRANSBRONCHIAL FORCEPS BIOPSY AND CRYOBIOPSY FOR PERIPHERAL PULMONARY LESIONS
Peripheral lung nodules seen on CT scans require a diagnostic evaluation as they commonly represent small, treatable lung cancers. In order to diagnose these lung lesions, bronchoscopy with small lung biopsies is often the preferred first step. However, this procedure is not always successful as not all biopsies obtain enough …
A Randomized Trial of Continuous Positive Airway Pressure (CPAP) for Sleep Apnea in Pregnancy
Please see attached protocol.
Network Control TMS fMRI
The University of Pennsylvania seeks young adults ages 18-28 for a research study. The purpose of this study is to use different types of MRI scans to find individualized TMS (transcranial magnetic stimulation) targets and compare how the brain responds. We are also interested in using TMS during a working …
Changes in the lymphatic system on MR Lymphangiography (MRL) in patients with congestive heart failure (CHF).
Observational study of adults with congestive heart failure and normal healthy participants using Magnetic Resonance Imaging (MRI) to compare changes in the lymphatic system (thin tubes and lymph nodes that run throughout the body).
An Open-Label Phase 2 Proof or Concept Study in Patients with C3 Glomerulopathy (C3G) or Immune-Complex Membranoproliferative Glomerulonephritis (IC-MPGN) Treated with ACH-0144471
This is an open-label study of 12 months of dosing with ACH-0144471. The study will enroll patients with biopsy-confirmed C3G or IC-MPGN who meet eligibility criteria for this study. There will be a multi-step screening process. At the initial screening visit, all screening eligibility assessments, except the renal biopsy, will …
NASA Specialized Center of Research (NSCOR) for Evaluating Risk Factors and Biomarkers for Adaptation and Resilience to Spaceflight: Emotional Valence and Social Processes in ICC/ICE Environments
NASAs vision for successful long-duration exploration missions depends on optimizing human performance, adaptability, and resiliency to reduce individual and crew behavioral risks. To date, the major emphasis in optimizing astronauts for their tolerance to prolonged spaceflight has involved human health and performance countermeasures as well as technologies and tools to …
A Prospective Randomised Trial of Early LV Venting Using Impella CP for Recovery in patients with cardiogenic managed with VA ECMO (REVERSE)
Veno-arterial (VA) extra-corporeal membrane oxygenation (ECMO) is indicated as a haemodynamic rescue strategy in decompensated acute or chronic heart failure presenting as cardiogenic shock. VA ECMO has a number of effects on the circulation including (i) perfusing end-organs, (ii) ventricular unloading, and (iii) improved coronary perfusion. It is a bridge …
Utility of Esophageal Cooling Therapy for the Prevention of Thermal Injury During Atrial Fibrillation Ablation: an investigator initiated randomized blinded single center pilot study
This is a small scale pilot study to evaluate if esophageal cooling using the Attune Medical Esophageal Heat Transfer Device (EnsoETM) limits the frequency or severity of thermal injury during catheter ablation of atrial fibrillation. This prospective, randomized study will include 40 patients with symptomatic AF undergoing index PVI at …
Post Approval Study of the remed System
This Post Approval Study is a multi-center, prospective, open label, single arm cohort study to evaluate the long-term safety, long-term effectiveness, and survival rate in subjects implanted with the remed System from the remed System Pivotal Trial. Up to 94 subjects will be enrolled at up to 21 sites in …
Light Treatment Effectiveness (LITE) Study
Phototherapy delivered at home or the office are both common treatments for psoriasis but it is not known how well they compare to one another. The purpose of this study is to compare the effectiveness, safety (tolerability), and duration of treatment response at 12 weeks of home versus office-based NB-UVB phototherapy …
