Found 706 clinical trials
Low-Dose Naltrexone to Improve Physical Health in Patients with Vasculitis (LoDoNaVasc)
The purpose of this study is to see whether a drug called naltrexone improves health-related quality of life in patients with vasculitis. Naltrexone is a prescription drug approved for a different reason at a higher dose than the dose used in this study. However, “low dose naltrexone” is widely used, …
UPCC 11417: A Phase 3 Multicenter Randomized Open-Label Study of Guadecitabine (SGI-110) versus Treatment Choice in Adults with Previously Treated Acute Myeloid Leukemia
Request for collaborative review: WIRB serving as IRB of record.
Multicenter randomized double-blind parallel-group add-on superiority study to compare the efficacy and safety of ponesimod to placebo in subjects with active relapsing multiple sclerosis who are treated with dimethyl fumarate (Tecfidera )
This is a study to find out whether patients with active forms of Relapsing Multiple Sclerosis (RMS) who are treated with dimethyl fumarate (Tecfidera®) can be treated better by the addition of ponesimod (study drug). The purpose is also to evaluate the effect on disability and the safety of these …
An Open-Label Safety and Tolerability Study of Chronic Intermittent Use of Diazepam Buccal Soluble Film (DBSF) in Adult Subjects With Epilepsy.
You are being asked to be in this study because you have epilepsy and you take epilepsy medication. Aquestive Therapeutics (the study Sponsor) has begun a research study of an investigational drug called Diazepam Buccal Soluble Film or DBSF as a possible treatment for patients with epilepsy. An investigational drug …
Multicenter Interventional Lymphangioleiomyomatosis Early Disease Trial (MILED Trial)
This application is a request to execute a reliance agreement with the Cincinnati Children's Hospital Medical Center (CCHMC) IRB.
Zoster Eye Disease Study (ZEDS): A multi-center randomized double-masked placebo-controlled study of valacyclovir in immunocompetent subjects with a history of dendriform epithelial keratitis stromal keratitis endothelial keratitis and/or iritis due to Herpes Zoster Ophthalmicus (HZO) within the year prior to enrollment.
Request to rely on the lead site IRB, see attached documents
UPCC 25417: A Randomized Phase 3 Study to Evaluate the Efficacy and Safety of Daratumumab in Combination with Cyclophosphamide Bortezomib and Dexamethasone (CyBorD) Compared With CyBorD Alone in Newly Diagnosed Systemic AL Amyloidosis
Request for collaborative review: Sterling IRB serving as IRB of record.
A Randomized Trial of Pessary in Singleton Pregnancies with a Short Cervix
Preterm birth is the primary driver of perinatal morbidity and mortality affecting approximately 11% of all newborns in the United States.1 Of the 4 million neonatal deaths that occur annually around the world, more than a quarter are the result of preterm birth.2 A short cervix by ultrasound has been …
BRCA Founder OutReach (BFOR) Study
The BRCA Founder Outreach (BFOR) Study is a new research initiative. BFOR seeks to increase access to testing for one of the most common tests for hereditary cancer, BRCA genetic mutations. These mutations of BRCA genes are associated with greater risks for several types of cancer, including breast, ovarian, and prostate …
