Found 706 clinical trials
A Phase 1b Multicenter Open-Label Safety Tolerability and Activity Study of SYNT001 in Subjects with Chronic Stable Warm Autoimmune Hemolytic Anemia (WAIHA)
WAIHA is caused by antibodies (proteins) that attach to red blood cells and causes their destruction. This causes anemia, which means the red blood cell count in the body becomes low. This medical research study is being done to find out more information about the investigational drug SYNT001 for the …
Detection of cell-free circulating tumor DNA in patients with glioblastma undergoing treatment with first-line chemoradiotherapy
Glioblastoma (GBM) is the most common primary brain tumor in adults and is uniformly fatal. During standard adjuvant treatment for GBM following initial surgical resection of the tumor, patients are treated with a combination of radiation and chemotherapy. During and after this adjuvant treatment, patients are monitored for disease progression …
A Phase 1 Study of the Highly-selective RET
This is a phase 1 study with Highly-selective RET inhibiter, Blu-667, in patients with Thyroid Cancer, Non-Small cell lung cancer and other advanced solid tumors. The study will be conducted at multiple centers in the United States and Europe. the purpose of this trial is to determine the maximum tolerated …
A Randomized Multicenter Phase 2 Study of DSP-7888 Dosing Emulsion in Combination with Bevacizumab versus Bevacizumab Alone in Patients with Recurrent or Progressive Glioblastoma following Initial Therapy
The BBI-DSP-7888-201G trial is designed to compare the overall survival (OS) between treatment with DSP-7888 Dosing Emulsion plus bevacizumab (Bev) versus Bev alone in patients with recurrent or progressive glioblastoma multiforme (GBM) following initial therapy. This is a randomized, active-controlled, multicenter, open-label, parallel groups, Phase 2 study. Approximately 200 patients …
Randomized Controlled Trial Examining the Effects of Meal Timing Among Obese Individuals
Normal 0 false false false EN-US X-NONE X-NONE We are currently screening for this study, but all in-person visits are on hold until the COVID-19 virus state of emergency is lifted. The timing of food consumption is now recognized as a significant contributor to body weight regulation and metabolic functioning. …
UPCC 35217: A Phase 1B/2 Open label study of Niraparib plus either Ipilimumab or Nivolumab in patients with advanced Pancreatic Cancer who have achieved stability on platinum- based therapy
The main purpose of this study is to look at the effectiveness, safety, and anti-tumor activity (preventing growth of the tumor) of the drugs niraparib with either ipilimumab or nivolumab on patients and their pancreatic cancer.
Acute and Long-term Effects of E-Cigarette Aerosol Inhalation on Biomarkers of Endothelial Function and Vascular Reactivity
The purpose of this study is 1) to examine the acute effects of nicotine free e-cigarette aerosol on vascular function in healthy, non-smokers and 2) to examine and compare vascular function in healthy smokers chronically exposed, at baseline and after 12 months, to nicotinized e-cigarette aerosol versus conventional cigarettes as …
A Pilot Study to Evaluate the Effect of CT1812 Treatment on A-beta Oligomer Displacement into CSF in Subjects with Mild to Moderate Alzheimer's Disease
Cognition Therapeutics is developing an oral formulation of CT1812 to treat AD and mild cognitive impairment. This is a multi-center, Phase 1b, randomized, double-blind, placebo-controlled parallel-group trial in adults with mild to moderate AD, sponsored by the NIH. The primary purpose of this study is to evaluate target engagement of …
Legionella Pneumonia's Effect on Olfactory Function
The goal of this study is to determine whether those who have had Legionnaires' disease suffer smell loss.
Autism Spectrum Program of Excellence
The goal of the ASPE study is to investigate the genetic basis of Autism spectrum disorder (ASD) and autism-related traits.Individuals 3 years old or older with a diagnosis (or suspected diagnosis) of autism spectrum disorder without intellectual disability may be eligible to participate. We are also recruiting individuals with a deletion or …
