Found 706 clinical trials
Extreme Phenotypes and Obstructive Sleep Apnea
The purpose of this study is to understand the relationship between obesity and obstructive sleep apnea. Obstructive sleep apnea typically causes daytime sleepiness and fragmented (broken up) sleep. Obesity is thought to be the most important risk factor for sleep apnea, yet we currently do not understand how obesity increases …
Generation Study
The Generation study is a clinical research study for individuals ages 60 to 75 with an increased genetic risk of developing clinical symptoms of Alzheimer’s disease. The study is enrolling persons who have two copies of the APOE4 gene An employee of the investigative site or an immediate family member …
XXXXXX- Xenon & Neural Inertia
This pilot study involves the administration of xenon gas via the ENHANCER 3000 delivery system to 12 healthy adult volunteers; xenon concentrations will range from 0% to up to 75%. Subjects will wear an Actiwatch for 7 days and nights prior to xenon administration (Study Day) and 7 days/nights afterwards. …
Trauma Induced Coagulapathy and Inflammation
While a number of factors are known to be associated with the development of trauma induced coagulopathy (TIC), inflammation, and multi-organ failure, we currently cannot predict which patients are at risk for developing these life-threatening conditions with any certainty. In this prospective observational study, we will investigate the many factors …
Bone Water and Mineralization Measured by Nuclear Magnetic Resonance
Post-menopausal osteoporosis is a major public health issue affecting millions of women. However, the microstructural implications of the disorder on cortical bone, the dominant bone type of the skeleton, are poorly understood and currently cannot be evaluated in vivo. This study, which utilizes new quantitative MRI methods, provides a path …
AMC 083 / UPCC 12716: Tissue Acquisition for Analysis of Prognostic Factors Immunology and Genetic Progression of HIV-1 Associated Malignancies
The main purpose of this study is to collect tissue from people diagnosed with HIV-associated cancer. We will use these samples to look for genetic changes associated with HIV- and other virus-related cancers. This may lead to better ways of preventing, detecting, and treating HIV-associated cancers.
Intratumoral Gene Mediated Cytotoxic Immunotherapy (GMCI) For Resectable Non-Small Cell Lung Cancer
Surgery is the best treatment for patients with Stage I or II lung cancer; however, nearly 60% of patients have recurrence. Additional immunotherapeutic agents given before surgery may be greatly reduce recurrence. This is a Standard Phase I, 3+3 dose escalation trial designed to evaluate the safety and toxicity of …
Pragmatic Phase Iii Randomized Trial of Proton vs. Photon Therapy for Patients with Non-Metastatic Breast Cancer Receiving Comprehensive Nodal Radiation: A Radiotherapy Comparative Effectiveness (RADCOMP) Consortium Trial
This is a pragmatic randomized clinical trial in which patients with locally advanced breast cancer will be randomized to either proton or photon therapy and followed longitudinally for cardiovascular morbidity and mortality, health-related quality of life (HRQOL), and cancer control outcomes. We hypothesize that proton therapy, as part of multi-modality …
KCP-330-020
The purpose of this study is to see if the investigational drug, selinexor, has any effects in eligible participants with advanced unresectable dedifferentiated liposarcoma (DDLS). Selinexor will be given at a fixed oral dose of 60mg or placebo twice weekly on Days 1 and 3 during Weeks 1-6 of each …
Open-Labeled Trial Of Zepatier For Treatment Of Hepatitis C-Negative Patients Who Receive Heart Transplants From Hepatitis C-Positive Donors
Since 2006, there has been a 50% increase in the number of adults added to the heart transplant waitlist in the US. Yet the persistent organ donor shortage has led to only a 25% increase in the number of transplants, and a 25% increase in the number of patients removed …
