Found 706 clinical trials
A First-in-Human Study of EOS301984 as Monotherapy or Combination Therapy in Adult Participants With Advanced Solid Tumors
APT-008 is an open-label, Phase I/Ib, dose escalation and expansion cohort study to evaluate the safety, tolerability, Pharmacokinetic (PK), Pharmacodynamic (PD), and preliminary efficacy of EOS301984 as monotherapy and in combination with other anticancer therapies in participants with advanced solid tumors.
Cochlear Implant Speech in Noise Processing
The study will help us in understanding the neural mechanisms by which listeners with a cochlear implant detect speech in noisy environments. 123
HCMR Novel Predictors of Outcome in Hypertrophic Cardiomyopathy
The Specific Aim of this study is to develop a predictive model of cardiovascular outcomes in hypertrophic cardiomyopathy (HCM) by: 1) using exploratory data mining methods to identify demographic, clinical, and novel cardiac magnetic resonance imaging, genetic and biomarker variables associated with the outcomes and 2) develop a score from …
A study to evaluate an oral medication, Siponimod (BAF312), in patients with Secondary Progressive Multiple Sclerosis
The main purpose of the study is to see how effective and safe BAF312 is compared to a Placebo in patients with Secondary Progressive MS. A placebo is a “pill” (capsule or tablet) with no medicine inside. A placebo is used to make sure that the changes you report are …
Estriol and Cognition in Multiple Sclerosis
The purpose of this study is to determine whether the combination of treatment with available MS therpies and estriol has an effect on cognitive function and disease activity and outcomes.
Child Nutrition Study
The University of Pennsylvania is seeking children (ages 7 to 9) and their mother to participate in a nutrition research study. Children will be asked to eat breakfast, lunch, and dinner in our center once a week for two weeks. Each visit will last from 8:00AM until 5:30PM. Children will …
TactiCath Post Market Approval Study
The purpose of the research study is to obtain additional information safety and effectiveness of an FDA approved catheter when used to treat patients with Paroxysmal atrial fibrillation.
A brief treatment on PTSD symptoms in pregnancy
We are looking for women to participate in a research study on psychotherapy for symptoms of Post-Traumatic Stress Disorder (PTSD) during pregnancy. The study will involve: screening questionnaires and a baseline visit to determine eligibility; Participation in a computer based stress task; Four weekly visits (30-45 minutes) with a psychologist …
Inspire Upper Airway Stimulation System for Obstructive Sleep Apnea: Post Approval Study
Patients with Obstructive Sleep Apnea (OSA) who are interested in pursuing surgical treatment may be candidates for the Inspire device, an FDA-approved upper airway stimulation device that can help to treat OSA. This trial is collecting long-term safety and efficacy data in participants that are implanted with the Inspire device.
Hormone effects in smoking addiction
The purpose of this study is to determine whether progesterone is helpful in reducing withdrawal symptoms, cigarette cravings, and smoking behavior. This study will also use brain imaging to measure the possible effects of progesterone on your brain chemicals. Healthy male and non-pregnant female smokers are invited to screen for …
