Opioid Use Disorder Clinical Trials

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Effects of Mu-opiate receptor engagement on the persistence of HIV-associated activation and viral reservoirs in individuals receiving medication assisted treatment for opioid use disorder

The primary objective of this proposal is to conduct a clinical study to establish whether chronic engagement of mu-opioid receptor (MOR) by full (methadone) or partial (buprenorphine + naloxone) agonists is a major factor in sustaining bacterial translocation and immune activation modulating in ART suppressed individuals with opioid use disorder …

Evaluation of in vivo Neuroinflammation Using 18F-NOS (PET/CT) in HIV Positive and Negative Subjects with Opioid Use Disorder and Healthy Controls

Study Purpose: The goal of this study is to learn more about how opiate use and HIV affects inflammation in the brain. We will study this using a type of Positron Emission Tomography (PET/CT) scan using a radioactive imaging drug called 18F-NOS that can be used to measure inflammation in …

A Pilot Proof of Concept Single-Center Study of the Use of Oritavancin in Systemic Staphylococcus aureus Infections in Patients with Opioid Use Disorder

The study participants will be in the study for approximately 2 months including the screening, intervention phase and the 6 weeks of follow-up time

Effects of mu-opiate receptor engagement on microbial translocation and residual immune activation in HIV-infected, ART suppressed opioid use disorder patients initiating medication-assisted treatment

The purpose of this research study is to examine the impact of medications (methadone, buprenorphine, or extended-release naltrexone) used to treat opioid use disorder on the immune system — the body’s ability to fight infection. The study will try to find out how these opioid treatment medications affect immune function.