Neoplasm Metastasis Clinical Trials

A study to evaluate an oral medication, Siponimod (BAF312), in patients with Secondary Progressive Multiple Sclerosis

The main purpose of the study is to see how effective and safe BAF312 is compared to a Placebo in patients with Secondary Progressive MS. A placebo is a “pill” (capsule or tablet) with no medicine inside. A placebo is used to make sure that the changes you report are …

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Secondary Distribution of HIV Self-Tests: an Innovative Strategy for Promoting Partner Testing and Reducing Risk

An Open-label Single-arm Single-dose Prospective Multicenter Phase 2b Study to Establish Image Interpretation Criteria for 18F-Fluciclovine Positron Emission Tomography (PET) in Detecting Recurrent Brain Metastases after Radiation Therapy (PURSUE)

The purpose of this study is to take initial steps to address this area of diagnostic unmet need by defining image interpretation criteria for 18F-fluciclovine PET scans in detecting recurrent brain metastases in adults with suspected recurrence after radiation therapy.

A Study to Evaluate the Safety and Efficacy of Image Guided Surgery using Indocyanine Green for Intramolecular Imaging of Solid Tumors Compared to Standard of Care (TumorGlow) (PRIME)

The high rates of recurrence suggest that surgeons are unable to completely detect and remove primary tumor nodules in a satisfactory manner as well as lingering metastases in sentinel lymph nodes. There is some data to suggest that near infrared imaging can can improve on negative margins.

A Phase 2 Randomized Controlled Dose-titration Open-Label Study Evaluating the Safety and Efficacy of BIV201 in Addition to Standard of Care Compared to Standard of Care to Reduce the Recurrence of Ascites and Complications in Patients with Refractory Ascites Secondary to Decompensated Liver Cirrhosis

TBD

Cancer detection rate of Abbreviated (Fast) Breast MRI (AB-MR) after negative Digitial Breast Tomosynthesis in Women status post Conservation Therapy (BCT)

In addition, the shorter time interval to the ipsilateral breast cancer recurrence from completion of treatment, is associated with increased risk of developing distant metastasis and breast cancer mortality. We will assess additional cancer detection with fast MRI after negative mammography in the ipsilateral as well as the contralateral breast.

A phase II open-label study of ONC201 in adults with recurrent high-grade glioma

The primary objective is to estimate the overall response rate (ORR) of ONC201 in this population. In addition, secondary objects will be to assess the safety, toxicities and tolerability of ONC201 in adults with recurrent high-grade glioma and estimate the median PFS, PFS at 2 and 6 months (progression-free survival …

A Phase 3 Randomized 3-Part Study To Investigate The Efficacy And Safety Of Dupilumab In Adult And Adolescent Patients With Eosinophilic Esophagitis

Part C: To assess the safety and efficacy of dupilumab treatment in adult and adolescent patients with EoE after up to 52 weeks of treatment as assessed by histological and clinical measures. The secondary objectives of the study are: To evaluate the safety, tolerability, and immunogenicity of dupilumab treatment for …

Intratumoral Gene Mediated Cytotoxic Immunotherapy (GMCI) For Resectable Non-Small Cell Lung Cancer

The primary end-point of the study is to determine maximum tolerated dose (MTD) and safety of AdV-tk/valacyclovir when combined with standard surgery and chemotherapy and/or radiation therapy. The secondary objectives are is to determine gene transfer efficiency and the effect of rAd-IFNa on the histology and immune profile of the …