Viral Infections Clinical Trials

DCPMS: Dialated Cardiomyopathy Precision Medicine Study

This study aims to understand the effects of potential familial/genetic links in an otherwise unclear origin of a patient's heart disease.

Secondary Distribution of HIV Self-Tests: an Innovative Strategy for Promoting Partner Testing and Reducing Risk

A Multiple-Site Phase 1/2 Safety and Efficacy Trial of AGTC 402 a Recombinant Adeno-associated Virus Vector Expressing CNGA3 in Patients with Congenital Achromatopsia Caused by Mutations in the CNGA3 Gene

Achromatopsia is an inherited retinal disorder characterized by markedly reduced visual acuity, nystagmus, photoaversion (intolerance to bright light), a small central scotoma, eccentric viewing, and complete or severe loss of color discrimination. The genetic mutations of the disease can be established in the majority of individuals. Approximately 25% are caused …

Lymph Node Fine Needle Aspiration to Study Immune Responses to Vaccinations

By studying lymph node cells, we hope to learn more about how vaccines work, including new vaccines such as ones developed against the COVID-19 virus. What we learn may help us make more effective vaccines in the future.

A Randomized Controlled Trial of Women Involved in Supporting Health (WISH), a Peer-Led Intervention to Improve Postpartum Retention in HIV Care

We are conducting this study to test the benefits of a program led by peer facilitators, Women Involved in Supporting Health (WISH), which is designed to increase the ability, the skills and social support necessary in order to stay in care and keep the virus under control after delivery. The …

AMC 083 / UPCC 12716: Tissue Acquisition for Analysis of Prognostic Factors Immunology and Genetic Progression of HIV-1 Associated Malignancies

We will use these samples to look for genetic changes associated with HIV- and other virus-related cancers. This may lead to better ways of preventing, detecting, and treating HIV-associated cancers.

A Phase III Randomized Placebo-Controlled Study to Examine the Efficacy and Safety of DAS181 for the Treatment of Lower Respiratory Tract Parainfluenza Infection in Immunocompromised Subjects

This purpose of this study is to see if an investigational inhaled medication is safe and effective for the treatment of parainfluenza virus(PIV) in patients with weakened immune systems. Key eligibility criteria are being diagnosed with PIV having received a solid organ or stem cell transplant at any time in …

An Adapted Friendship Bench for adolescents living with and at risk for HIV in Botswana: a mental health needs assessment and feasibility study

We will assess depression, anxiety, and substance use in adolescents at risk for a living with HIV. We will also assess the feasibility, acceptability and safety of a previously adapted version of the Friendship Bench (Bench). The Friendship Bench is a youth lay counsellor technique modelled after a previous study …

Suicide and Trauma in Persons living with HIV

Rates of posttraumatic stress disorder (PTSD), substance use, sleep disorders and suicide are disproportionately higher in persons living with HIV (PLWH). The Syndemic Model of Substance Abuse, Intimate Partner Violence, and HIV (SAVA Syndemic), refers to the frequent co-occurrence and mutual influence between these conditions. The SAVA Syndemic has not …

Effects of mu-opiate receptor engagement on microbial translocation and residual immune activation in HIV-infected, ART suppressed opioid use disorder patients initiating medication-assisted treatment

The purpose of this research study is to examine the impact of medications (methadone, buprenorphine, or extended-release naltrexone) used to treat opioid use disorder on the immune system — the body’s ability to fight infection. The study will try to find out how these opioid treatment medications affect immune function. …