DCPMS: Dialated Cardiomyopathy Precision Medicine Study

This study aims to understand the effects of potential familial/genetic links in an otherwise unclear origin of a patient's heart disease.

Universal COVID-19 Biobank: A subset of the Penn Medicine BioBank

The Universal COVID-19 Biobank – a component of the Penn Medicine Biobank – is collecting and storing biological specimens as well as information about people who may or may not have been exposed to the SARS-CoV-2 virus as well as those who have developed COVID-19 disease. This information will be …

AMC 083 / UPCC 12716: Tissue Acquisition for Analysis of Prognostic Factors Immunology and Genetic Progression of HIV-1 Associated Malignancies

The main purpose of this study is to collect tissue from people diagnosed with HIV-associated cancer. We will use these samples to look for genetic changes associated with HIV- and other virus-related cancers. This may lead to better ways of preventing, detecting, and treating HIV-associated cancers.

A Phase III Randomized Placebo-Controlled Study to Examine the Efficacy and Safety of DAS181 for the Treatment of Lower Respiratory Tract Parainfluenza Infection in Immunocompromised Subjects

This purpose of this study is to see if an investigational inhaled medication is safe and effective for the treatment of parainfluenza virus(PIV) in patients with weakened immune systems. Key eligibility criteria are being diagnosed with PIV having received a solid organ or stem cell transplant at any time in …

Lymph Node Fine Needle Aspiration to Study Immune Responses to Vaccinations

The purpose of this study is to obtain lymph node samples to understand how the immune system makes a response to vaccinations. In particular, we will study the immune cells within lymph nodes, where we think important parts of the vaccine response occur. We believe that if we study only …

Secondary Distribution of HIV Self-Tests: an Innovative Strategy for Promoting Partner Testing and Reducing Risk

Changes in Bone Quality Sarcopenia and Fat Distribution in HIV/HCV Patients after HCV Therapy

Coinfection with hepatitis C virus (HCV) is common among HIV infected patients. HIV exacerbates HCV-related metabolic complications, and coinfected patients have a higher risk of sarcopenia, visceral adiposity, hepatic steatosis, and bone fracture than those with HCV alone, HIV alone, or uninfected persons. Understanding these associations in HIV+/HCV+ patients, how …

HOPE in Action Prospective Multicenter Clinical Trial of HIV+ Deceased Donor Kidney Transplants for HIV+ Recipients

Use of an HIV+ deceased donor could increase the risk of death, transplant-related or HIV-related complications; alternatively with effective antiretroviral treatment and careful HIV+ donor selection, these risks may be comparable to kidney transplant using an HIV-negative donor. We hypothesize that receiving a kidney transplant from an HIV+ donor will …

Testing Novel Pharmacogenetic and Adherence Optimization Treatments to Improve the Effectiveness of Smoking Cessation Treatments for Smokers with HIV

The research study is being conducted to examine the effects of personalized smoking cessation medication treatment in order to help people with HIV/AIDS to quit smoking. During the study, participants will take either varenicline (brand name Chantix®) or use the nicotine patch, and they will receive smoking cessation therapy with …

MRI Assessment of Hip Fracture Risk and Therapy Response in HIV/HCV Coinfection

Project Summary Within a year of hip fracture 20-30% of patients die, and 50% percent lose the ability to walk. A consensus exists that infection with the human immunodeficiency virus (HIV) or the hepatis C virus (HCV) increases the likelihood of fracture risk. Co-infection with HIV and HCV is prevalent …