Pain Clinical Trials

Protocol Title: An Open-label Phase 2 Proof-of-Concept Study in Patients with C3 Glomerulopathy (C3G) or Immune- Complex Membranoproliferative Glomerulonephritis (ICMPGN) Treated with ACH-0144471 (ACH471-205)

A pilot randomized control trial to determine the feasibility of a hypnosis intervention for the treatment of bladder pain syndrome/interstitial cystitis.

The use of hypnosis for bladder pain syndrome is experimental.

Dose Escalation Study of Intravenous PRX004 in Subjects with Amyloid Transthyretin (ATTR) Amyloidosis

You are being asked to take part in this research study because you have ATTR amyloidosis with peripheral neuropathy (nerve damage that occurs in the extremities of the body and may cause pain, such as foot pain or hand pain). Transthyretin (TTR) is a naturally occurring protein. In ATTR amyloidosis, TTR …

Low-Dose Naltrexone to Improve Physical Health in Patients with Vasculitis (LoDoNaVasc)

However, “low dose naltrexone” is widely used, without insurance coverage, for a wide range of conditions associated with pain or fatigue. We hope to learn more about the impact of low dose naltrexone on the symptoms caused by vasculitis.

Epidemiological study to characterize the prevalence and distribution of lipoprotein (a) levels among patients with established cardiovascular disease.

Similar to other blood lipids, such as the "bad cholesterol", lipoprotein (a) levels were found to be associated with the risk of hardening of the arteries, known as atherosclerosis, which leads to conditions such as heart attacks, stroke, or peripheral artery disease (severe pain in legs while walking or lower …

An International, Open Label, Randomised Controlled Trial Comparing Rituximab with Azathioprine as Maintenance Therapy in Relapsing ANCA-Associated Vasculitis  

Vasculitis is inflammation of blood vessels in your body. The exact cause is unknown, but we do know that it is an autoimmune condition. This means that your body’s own immune system, that normally fights infection, is overactive and is damaging your own blood vessels. Vasculitis can affect almost any …

Evaluation of Transcatheter Aortic Valve Replacement Compared to SurveilLance for Patients with AsYmptomatic Severe Aortic Stenosis

Fainting or pre-fainting episodes to including severe dizziness, chest pain, limiting shortness of breath or decreased exercise tolerance, lack of increase or drop in the top number on your blood pressure reading, or significant irregular heart beats greater or equal to four consecutive irregular heart beats.

Cardiovascular Inflammation Reduction Trial (CIRT): A randomized double-blind placebo controlled event-driven trial of weekly low-dose methotrexate (LDM) in the prevention of recurrent cardiovascular events among stable post-myocardial infarction patients with type 2 diabetes or metabolic syndrome

The combination of problems tends to occur together and raise your risk of heart disease and diabetes. Methotrexate is a drug commonly used to reduce inflammation (pain and swelling) in the joints of people with rheumatoid arthritis. It has been noticed that patients taking methotrexate for their arthritis seem to …

To Serenade or To Sedate? That is Still The Question - A Followup Trial On Anxiolytic Options Before Peripheral Nerve Blocks

The research study is being conducted to determine if there are differences in anxiety scores, heart rate, blood pressure, and oxygen status when using sedation medication versus the patient's choice of listening to music while undergoing a peripheral nerve block before his or her surgery. The patient will either receive …

Study to evaluate the safety and efficacy of Avacopan in subjects with moderate to severe hidraentis suppurativa

You are being invited to participate in a research study because you have hidradenitis suppurativa (HS), also called acne inversa. Avacopan is an investigational drug being studied to learn if it is safe and effective for the treatment for HS.