Brain Injury Clinical Trials

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Transforming Research and Clinical Knowledge in Traumatic Brain Injury

Traumatic brain injury (TBI) is among the leading causes of death and disability worldwide with enormous social and economic impacts. The heterogeneity of TBI, combined with the lack of precise outcome measures, have been central to the discouraging results from numerous clinical trials.

Cerebrovascular reactivity assessed with functional near-infrared spectroscopy as a biomarker of traumatic microvascular injury after traumatic brain injury

Traumatic cerebrovascular injury (TCVI) is common after traumatic brain injury (TBI) and an attractive target for therapeutic intervention. We will longitudinally measure cerebrovascular reactivity (CVR) by functional near-infrared spectroscopy (fNIRS) in acute (3 days from injury), subacute, and chronic phases after TBI as a biomarker of TCVI as compared to …

Transforming Research and Clinical Knowledge in Traumatic Brain Injury: Biomarker Project

We will use these imaging and biological markers, “biomarkers”, to relate the severity of the brain injury with brain recovery (neurological outcome) and post-injury symptoms. The long-term goal of this study is to provide physicians with the knowledge and tools they need to evaluate an individual’s recovery following a brain …

The REFLECT Trial: A Randomized Evaluation oF the TriGuard HDH Cerebral Embolic Protection Device and the TriGUARD 3 Cerebral Embolic Protection Device to Reduce the Impact of Cerebral Embolic LEsions after TransCatheter Aortic Valve ImplanTation

The purpose of the study is to assess whether the TriGUARD 3 can prevent death, stroke, more subtle signs of brain injury, and/or silent brain injury as measured by a magnetic resonance imaging (MRI) study of the brain.

A study of human multi-sensory integration: A neurophysiologic correlate of conscious perception

This is a prospective dual parallel arm human subject study aimed at determining the relationship between level of sedation (consciousness) and features of multi and uni-sensory evoked potentials with the ultimate goal of developing novel means of detecting consciousness under anesthesia with potential for application to other clinical settings such …

Transforming Research and Clinical Knowledge in Traumatic Brain Injury Epileptogenesis Project

TRACK-TBI EPI is an observational study of the TRACK-TBI longitudinal cohort. Subjects will be contacted 2-5 years after their index TBI for consent to a phone interview. Those who screen positive for possible post-traumatic epilepsy will be invited for an in person visit, which will involve a clinical evaluation by …