Anemia Clinical Trials

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SMaRT Blood: Single-unit versus Multiple-unit pRBC Transfusion in non-acute postpartum anemia

Blood transfusion is often recommended for women who have anemia (low blood counts) after delivering a baby. Currently, many doctors give 2 units, or packets, of blood because they expect that everyone will need 2.

A Phase 2 Study of PTG-300 in Non-Transfusion Dependent (NTD) and Transfusion-Dependent (TD) Beta-Thalassemia Subjects with Chronic Anemia.

This is a Phase 2 open-label, single-arm design with dose escalation by subject cohort and with the potential for individual titration (dose increase or decrease) within each cohort. Five PTG-300 dose levels/regimens are planned to be tested for each subpopulation of beta-thalassemia (NTD and TD) on separate arms: Cohort 1: …

A Phase 1b Multicenter Open-Label Safety Tolerability and Activity Study of SYNT001 in Subjects with Chronic Stable Warm Autoimmune Hemolytic Anemia (WAIHA)

WAIHA is caused by antibodies (proteins) that attach to red blood cells and causes their destruction. This causes anemia, which means the red blood cell count in the body becomes low. This medical research study is being done to find out more information about the investigational drug SYNT001 for the …

A Phase 3 Randomized Double-blind Placebo-controlled Study to Assess the Efficacy and Safety of BIVV009 in Patients with Primary Cold Agglutinin Disease Without a Recent History of Blood Transfusion (Cadenza)

This is a randomized, double-blind, placebo-controlled, multicenter study in patients with primary cold agglutinin disease (CAgD) without a recent history of blood transfusion. Eligible patients will receive study drug (BIVV009 or placebo) and undergo safety and efficacy assessments for 6 months (26 weeks) during Part A. Following completion of the …