Stress Clinical Trials

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Treatment for Mixed Urinary Incontinence: Mid-urethral Sling vs. Botox A

ABSTRACT Mixed urinary incontinence (MUI), defined as the presence of both stress urinary incontinence and urgency urinary incontinence, is a challenging condition for which clinicians frequently use multiple sequential treatments that have undergone limited head to head comparison in rigorous clinical trials.

Serenity Study: Lowering High Blood Pressure with Stress Management Techniques

The Serenity Study is a voluntary research study that will investigate different approaches to stress management in order to help lower blood pressure. You may be eligible to participate if you: have blood pressure in the pre-hypertensive range (systolic BP 120-139 or diastolic BP 80-89), are a healthy adult between …

Multicenter open-label study to evaluate efficacy of gadobutrolenhanced cardiac magnetic resonance imaging (CMRI) for detection of significant coronary artery disease (CAD) in subjects with known or suspected CAD by a blinded image analysis

The primary efficacy objectives of this study are to demonstrate that sensitivity and specificity of gadobutrol-enhanced CMRI exceed prespecified minimum performance thresholds (MPT) of 60% and 55%, respectively and to show superior sensitivity over unenhanced wall motion CMRI at vasodilator rest/stress for the detection of significant coronary artery disease (CAD) …

Evaluation of Transcatheter Aortic Valve Replacement Compared to SurveilLance for Patients with AsYmptomatic Severe Aortic Stenosis

The physician may also determine the patient asymptomatic after a thorough assessment of patient history if the patient is unable to perform a stress test. The subjects vessels must be confirmed large enough for transfemoral access prior to being randomized to the 1:1 ratio to either receive transcatheter aortic valve …

Study of Flurpiridaz (18F) Injection for Positron Emission Tomography (PET) Imaging for Assessment of Myocardial Perfusion in Patients Referred for Invasive Coronary Angiography Because of Suspected Coronary Artery Disease.

Patients can be considered for enrolment if: - They are being scheduled via written documentation at the time of enrolment to undergo ICA, and - They have undergone a clinically indicated SPECT study which meets all study-specified imaging and stress testing criteria, or are willing to undergo SPECT MPI for …

Suicide and Trauma in Persons living with HIV

Rates of posttraumatic stress disorder (PTSD), substance use, sleep disorders and suicide are disproportionately higher in persons living with HIV (PLWH). The Syndemic Model of Substance Abuse, Intimate Partner Violence, and HIV (SAVA Syndemic), refers to the frequent co-occurrence and mutual influence between these conditions.

Molecular Imaging of the Underlying Mechanism of Cardiotoxicity in Patients with Light Chain Amyloidosis using Positron Emission Tomography (PET/CT)

In one cohort positron emission tomography/computed tomography (PET/CT) imaging will be used to measure inducible nitric oxide synthase (NOS) expression in the heart as a marker oxidative stress and inflammation using an investigational radiotracer called 18F-NOS. In the other cohort PET/CT imaging will be used to measure amyloid deposition as …

Serenity for All

You are invited to participate in this online research survey, Serenity for All. We are aiming to get 100 people to complete this survey. In order to participate in this study, you have to be at least 18 years old.