Dementia Clinical Trials
A listing of Dementia medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
Found 34 clinical trials
A phase 2b double-blind randomised 5-arm vehicle-controlled dose ranging trial to evaluate the efficacy and safety of twice daily topical applications of delgocitinib cream 1 3 8 20 mg/g for 8 weeks in adult subjects with mild to severe atopic dermatitis.
The purpose of this clinical trial is to test different strengths of a new trial medication, delgocitinib cream 1, 3, 8, and 20 mg/g, and to investigate how treatment with delgocitinib cream affects atopic dermatitis (a type of eczema). key eligibility include: Age 18 years and above. Diagnosis of AD …
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- 19 Feb, 2024
- 1 location
A Phase 3 Multicenter Randomized Double- Blind Placebo- Controlled Study to Evaluate the Efficacy and Safety of AL001 in Individuals at Risk for or With Frontotemporal Dementia Due to Heterozygous Mutations in the Progranulin Gene
This is for people who have a confirmed progranulin gene mutation that causes frontotemporal dementia (FTD). Study particiants will need to have a spouse, family member, or friend participate in this study with them as a study partner.
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- 19 Feb, 2024
- 1 location
Longitudinal Early-Onset Alzheimer's Disease Study (LEADS) Protocol
Clinical/cognitive, imaging, biomarker, and genetic characteristics will be assessed across three cohorts: (1) early onset Alzheimer's Disease (EOAD) participants, (2) early onset non-Alzheimer's Disease (EO-nonAD) participants,and (3) cognitively normal (CN) control participants.
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- 19 Feb, 2024
- 1 location
Clinical Core Alzheimer's Disease Core Center (ABC)
The purpose of this study is to collect, store and analyze cognitive data and biological samples, such as blood and MRI imaging, from individuals without symptoms of memory loss and/or dementia. Our goal is to improve our understanding of age-associated brain changes and our ability to diagnosis and treat brain …
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- 19 Feb, 2024
- 1 location
A randomized double-blind placebo-controlled parallel group study to evaluate the efficacy and safety of CNP520 in participants at risk for the onset of clinical symptoms of Alzheimers Disease (AD)
The study will enroll cognitively unimpaired individuals who are between the ages of 60-75 years with at least one APOE4 allele (HMs or HTs) and, if HTs, with evidence of elevated brain amyloid. Cognitively unimpaired subjects defined as having a Mini-Mental State Examination (MMSE) total score greater than or equal …
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- 19 Feb, 2024
- 1 location
18-Month Study With an Open-Label Extension Phase to Confirm Safety and Efficacy of BAN2401 in Subjects With Early Alzheimers Disease
A total of 1566 subjects will be randomized in the Core Study across 2 treatment groups, (placebo and BAN2401 10 mg/kg, biweekly) according to a fixed 1:1 (placebo:BAN2401) schedule. Randomization will occur across 2 clinical subgroups (MCI due to AD/prodromal AD or mild AD dementia), and will be reasonably balanced, …
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- 19 Feb, 2024
- 1 location
Chronic insomnia and CSF markers of dementia
The purpose of this study is to identify the relationship between chronic sleep disturbance and chemicals in spinal fluid that are related to dementia and a molecule called orexin that helps regulate wakefulness and appetite in the brain. Individuals with sleep problems and good sleepers will be asked to participate.
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- 19 Feb, 2024
- 1 location
Healthy Patterns Sleep Intervention for Persons with Memory and Sleep Problems and their Caregivers
The Healthy Patterns Study intervention is a home-based activity intervention designed to introduce activities and education that promote healthy sleeping habits and improve well-being for those suffering with memory and sleep issues . Principal Investigator: Nancy A. Hodsgon, PhD, RN, FAAN, Nursing School, University of Pennsylvania
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- 19 Feb, 2024
- 1 location
Chronic insomnia and CSF markers of dementia - Phase 2
Longitudinal studies have found that sleep disturbance often precedes and increases risk for dementia by several years.The purpose of this study is to examine the relationship between chronic insomnia and dementia biomarkers and orexin levels found in cerebrospinal fluid (CSF).
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- 19 Feb, 2024
- 1 location
Language And Cognitive Impairment In Parkinson's Disease
This study is designed to determine the changes in the brain that occur during conditions of verbal stimulation in patients who have Parkinson’s Disease and Parkinson’s Disease with Dementia or Dementia with Lewy Bodies.
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- 19 Feb, 2024
- 1 location