Heart Failure Clinical Trials

AdaptResponse Clinical Investigation Plan

The purpose of the research study is looking at a new algorithm (step by step approach) for patients with heart failure who are indicated for an BiV (biventricular) pacing device.

Matching Perfusion and Metabolic Activity in HFpEF

This study will test whether Potassium Nitrate (KNO3), with and without Propionyl-L-Carnitine (PLC) and Nicotinamide Riboside (NR), improves submaximal exercise endurance and skeletal muscle oxidative phosphorylation capacity (SkM OxPhos) in participants with Heart Failure with Preserved Ejection Fraction (HFpEF). This study will also test whether the response to supplemental oxygen …

A Prospective Randomised Trial of Early LV Venting Using Impella CP for Recovery in patients with cardiogenic managed with VA ECMO (REVERSE)

Veno-arterial (VA) extra-corporeal membrane oxygenation (ECMO) is indicated as a haemodynamic rescue strategy in decompensated acute or chronic heart failure presenting as cardiogenic shock. VA ECMO has a number of effects on the circulation including (i) perfusing end-organs, (ii) ventricular unloading, and (iii) improved coronary perfusion.

Medtronic Evaluation of Multi-Electrode Phased RF Technology in Persistent Atrial Fibrillation

The Phased RF System includes the GENius Multi Channel Radio Frequency Ablation Generator and three anatomically designed, multi-electrode catheters: Pulmonary Vein Ablation Catheter GOLD (PVAC GOLD) Multi-Array Septal Catheter (MASC) Multi-Array Ablation Catheter (MAAC) INCLUSION CRITERIA History of symptomatic persistent or long-standing persistent atrial fibrillation defined as: o Persistent AF: …

A Clinical Study to Evaluate Ambulatory Counterpulsation for the Treatment of Advanced Heart Failure: A Feasibility Study

The purpose of this study is to: assess if the iVAS can help improve blood circulation, gain a better understanding of how this device could impact your health, determine human interaction with the device, and assess the portability of this device.

Cardiovascular function in leukemia patients: an observational prospective study

We have recently observed that patients with acute leukemia treated with anthracyclines develop a high rate of symptomatic heart failure. To avoid this life-threatening illness, early detection of cardiac dysfunction and implementation of cardioprotective therapies are crucial.

Efficacy of DE-MRI-Guided Fibrosis Ablation vs. Conventional Catheter Ablation of Atrial Fibrillation: The DECAAF II Study

You are being asked to participate in this study because you have atrial fibrillation and are planning to undergo an ablation procedure to treat this heart rhythm irregularity.

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