type 2 diabetes mellitus Clinical Trials

UPENN Case Test Trial 1 In Different Account (Do Not Make Any Change)

UPENN Case Test Trial 1 In Different Account (Do Not Make Any Changes)

“The Shift Worker’s Microbiome”

Individuals who work night shifts or rotating shift schedules are more likely to develop cardiovascular disease (stroke and heart attack) and diabetes (high blood sugar). This is thought to be related to the long-term disruption of these workers’ body clocks associated with changing or nighttime schedules.

Research Study for women with PCOS (Polycystic ovary syndrome)  

Healthy women ages 18-45 with Polycystic Ovary Syndrome (PCOS) are invited to screen for a study participation in an investigational drug study

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Normal Donor Human Bone Marrow Donation for Research

We are looking for healthy volunteers to donate bone marrow for research purposes. The Stem Cell & Xenograft Core provides bone marrow to laboratories on Penn’s campus researching leukemia and other blood disorders

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Comparison of the Short-Term Effect of Dietary Carbohydrate Restriction Versus Exogenous Ketone Supplementation on Myocardial Glucose Suppression and Timing to Achieve a State of Ketosis Using FDG PET/CT Serial Imaging

We will enroll up to 50 subjects in order to reach our target of 40 fully evaluable; 20 healthy volunteers and 20 patients with Type 2 diabetes mellitus. We will test whether dietary modification (ketogenic diet) or exogenous ketone administration will provide enhanced myocardial glucose suppression.

Effect of GLP-1 Agonist Therapy on Insulin Secretion in Adults with Pancreatic Insufficient Cystic Fibrosis and Abnormal Glucose Tolerance: a randomized open-label cross-over trial

Diabetes is a major co-morbidity in pancreatic insufficient cystic fibrosis (PI-CF) and associated with worse outcomes. While reduced -cell mass contributes to the insulin secretory defects that characterizes cystic fibrosis-related diabetes (CFRD), other modifiable determinants appear operative in the emergence and progression of abnormal glucose tolerance towards diabetes.