Wounds Clinical Trials

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Cerebrovascular reactivity assessed with functional near-infrared spectroscopy as a biomarker of traumatic microvascular injury after traumatic brain injury

Traumatic cerebrovascular injury (TCVI) is common after traumatic brain injury (TBI) and an attractive target for therapeutic intervention. We will longitudinally measure cerebrovascular reactivity (CVR) by functional near-infrared spectroscopy (fNIRS) in acute (3 days from injury), subacute, and chronic phases after TBI as a biomarker of TCVI as compared to …

Transforming Research and Clinical Knowledge in Traumatic Brain Injury

Traumatic brain injury (TBI) is among the leading causes of death and disability worldwide with enormous social and economic impacts. The heterogeneity of TBI, combined with the lack of precise outcome measures, have been central to the discouraging results from numerous clinical trials.

CYTOSORB REDUCTION OF FREE HEMOGLOBIN/ACUTE KIDNEY INJURY (AKI) DURING CARDIAC SURGERY - REFRESH II

Reliance Agreement Request - Please refer to WIRB

Basis: Evaluating Sirtuin Supplements To Benefit Elderly Trauma Patients (BES2T BET)

This randomized, double blind placebo controlled trial will investigate the impact of Basis on the functional recovery of elderly patients (65 years or older) admitted to the trauma service post-injury. Basis (or placebo) will be taken orally for 90 days. Bioactivity will be tracked daily. Functional, cognitive, and biochemical assays …

A Prospective Multicenter Non-Blinded Non-Randomized Study of the RelayPro Thoracic Stent-Graft in Subjects with Traumatic Injury of the Descending Thoracic Aorta

TBD

Trauma Induced Coagulapathy and Inflammation

In this prospective observational study, we will investigate the many factors that contribute to the development of trauma induced coagulopathy, post injury inflammation and the development of organ dysfunction in order to develop a multi scale computational algorhythm and ex vivo models capable of clinical prediction.

Suicide and Trauma in Persons living with HIV

Rates of posttraumatic stress disorder (PTSD), substance use, sleep disorders and suicide are disproportionately higher in persons living with HIV (PLWH). The Syndemic Model of Substance Abuse, Intimate Partner Violence, and HIV (SAVA Syndemic), refers to the frequent co-occurrence and mutual influence between these conditions. The SAVA Syndemic has not …

Transforming Research and Clinical Knowledge in Traumatic Brain Injury: Biomarker Project

The goal of this study is to better understand that which contributes to the long-term recovery of people who have sustained a traumatic brain injury. To better understand an individual’s recovery following a head-injury, we will measure and examine the chemicals released in the brain and blood following the injury.

Utility of Esophageal Cooling Therapy for the Prevention of Thermal Injury During Atrial Fibrillation Ablation: an investigator initiated randomized blinded single center pilot study

This is a small scale pilot study to evaluate if esophageal cooling using the Attune Medical Esophageal Heat Transfer Device (EnsoETM) limits the frequency or severity of thermal injury during catheter ablation of atrial fibrillation. This prospective, randomized study will include 40 patients with symptomatic AF undergoing index PVI at …