Pneumonia Clinical Trials

Secondary Distribution of HIV Self-Tests: an Innovative Strategy for Promoting Partner Testing and Reducing Risk

Measurement of Pulmonary Inflammation Using F-NOS Positron Emission Tomography (PET/CT) in E-cigarette Users

This is a 1 – 2 month study examining the extent of lung inflammation between e-cigarette smokers, cigarette smokers, and non-smokers using a new radio tracer, FNOS. FNOS is an experimental radio tracer used to look for inflammation in different parts of the body.

Convalescent Plasma for Severely Ill Hospitalized Participants with COVID-19 Pneumonia Caused by SARS-CoV-2

This open-label, controlled, phase 1 trial will assess the safety and efficacy of convalescent plasma in severely ill, hospitalized participants with pneumonia due to COVID-19. This study will enroll adults 18 years old and older, including pregnant women. A total of 80 eligible participants will be randomized to receive either …

A PHASE III RANDOMIZED DOUBLE-BLIND PLACEBO-CONTROLLED STUDY OF AEROVANC FOR THE TREATMENT OF PERSISTANT METHICILLIN-RESISTANT Staphylococcus aureus LUNG INFECTION IN CYSTIC FIBROSIS PATIENTS; SAV005-04

TBD

An Adapted Friendship Bench for adolescents living with and at risk for HIV in Botswana: a mental health needs assessment and feasibility study

We will assess depression, anxiety, and substance use in adolescents at risk for a living with HIV. We will also assess the feasibility, acceptability and safety of a previously adapted version of the Friendship Bench (Bench). The Friendship Bench is a youth lay counsellor technique modelled after a previous study …

Suicide and Trauma in Persons living with HIV

Rates of posttraumatic stress disorder (PTSD), substance use, sleep disorders and suicide are disproportionately higher in persons living with HIV (PLWH). The Syndemic Model of Substance Abuse, Intimate Partner Violence, and HIV (SAVA Syndemic), refers to the frequent co-occurrence and mutual influence between these conditions. The SAVA Syndemic has not …

Effects of mu-opiate receptor engagement on microbial translocation and residual immune activation in HIV-infected, ART suppressed opioid use disorder patients initiating medication-assisted treatment

The purpose of this research study is to examine the impact of medications (methadone, buprenorphine, or extended-release naltrexone) used to treat opioid use disorder on the immune system — the body’s ability to fight infection. The study will try to find out how these opioid treatment medications affect immune function. …

A Randomized Controlled Trial of Women Involved in Supporting Health (WISH), a Peer-Led Intervention to Improve Postpartum Retention in HIV Care

The purpose of the study is to learn more about programs that can improve the health and wellbeing of mothers and their babies during the period after delivery. Women living with HIV experience diverse health problems in the period directly after delivery. These problems are related to poor medical visit …

Changes in Bone Quality Sarcopenia and Fat Distribution in HIV/HCV Patients after HCV Therapy

Coinfection with hepatitis C virus (HCV) is common among HIV infected patients. HIV exacerbates HCV-related metabolic complications, and coinfected patients have a higher risk of sarcopenia, visceral adiposity, hepatic steatosis, and bone fracture than those with HCV alone, HIV alone, or uninfected persons. Understanding these associations in HIV+/HCV+ patients, how …

HOPE in Action Prospective Multicenter Clinical Trial of HIV+ Deceased Donor Kidney Transplants for HIV+ Recipients

Use of an HIV+ deceased donor could increase the risk of death, transplant-related or HIV-related complications; alternatively with effective antiretroviral treatment and careful HIV+ donor selection, these risks may be comparable to kidney transplant using an HIV-negative donor. We hypothesize that receiving a kidney transplant from an HIV+ donor will …