Allergy Clinical Trials

A listing of Allergy medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 327 clinical trials
A PHASE II STUDY EVALUATING THE EFFICACY AND SAFETY OF NIRAPARIB AND TUMOR-TREATING FIELDS IN RECURRENT GLIOBLASTOMA

Tumors harboring such genomic alterations have been described as maintaining a state of BRCAness, i.e. a phenocopy of BRCA1 and BRCA2 mutation that may render the cells sensitive to treatment with PARP inhibition.

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  • 19 Feb, 2024
  • 1 location
CMT Subtype Biomarkers and Outcome Measures

In order to prepare for clinical trials for CMT, there is ongoing work to develop more sensitive outcome measures, and there is a need for complementary biomarkers, particularly target engagement measures that can be used in clinical trials for candidate therapies.

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  • 19 Feb, 2024
  • 1 location
Cancer detection rate of Abbreviated (Fast) Breast MRI (AB-MR) after negative Digitial Breast Tomosynthesis in Women status post Conservation Therapy (BCT)

Women treated for primary breast cancer who undergo breast conservation therapy face an increased risk of developing a second breast cancer in the ipsilateral and the contralateral breast. Although mammographic screening is recommended annually, the sensitivity of mammography is limited in these patients due to the post treatment changes from …

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  • 19 Feb, 2024
  • 1 location
Pilot Study of EsoCheck Compared to Biopsies and Brush Cytology During Endoscopy for Evaluation of Eosinophilic Esophagitis

The aims of this study are to determine the feasibility and safety of EsoCheck compared with EGD and sensitivity and specificity of brush cytology and EsoCheck in a prospective cross-sectional pilot study of adult patients at the University of Pennsylvania with known EoE.

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  • 19 Feb, 2024
  • 1 location
UPCC 02419: An Open-label Single Arm Phase 2 Study to Evaluate Efficacy and Safety of Avapritinib (BLU-285) A Selective KIT Mutation-targeted Tyrosine Kinase Inhibitor in Patients with Advanced Systemic Mastocytosis

When increased in number or abnormal in function they release their contents resulting in allergic reactions and other related symptoms, which are also associated with mastocytosis.

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  • 19 Feb, 2024
  • 1 location
Multicenter open-label study to evaluate efficacy of gadobutrolenhanced cardiac magnetic resonance imaging (CMRI) for detection of significant coronary artery disease (CAD) in subjects with known or suspected CAD by a blinded image analysis

The primary efficacy objectives of this study are to demonstrate that sensitivity and specificity of gadobutrol-enhanced CMRI exceed prespecified minimum performance thresholds (MPT) of 60% and 55%, respectively and to show superior sensitivity over unenhanced wall motion CMRI at vasodilator rest/stress for the detection of significant coronary artery disease (CAD) …

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  • 19 Feb, 2024
  • 1 location
Cardiovascular function in leukemia patients: an observational prospective study

We will also examine whether these sensitive parameters of cardiac function identify patients who will develop cardiovascular events. This is a prospective, observational, single-center study.

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  • 19 Feb, 2024
  • 1 location
Comparing the effects of Oral Contraceptive Pills versus Metformin in the medical management of overweight/obese women with Polycystic Ovary Syndrome

The combination of OCP and metformin (OCP, through lowering androgens, and metformin, through improvement in insulin sensitivity) will likely decrease the prevalence of MetS, thereby altering the risk profile for the development of diabetes and possible cardiovascular disease (CVD) in young women with PCOS.

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  • 19 Feb, 2024
  • 1 location
Detection of cell-free circulating tumor DNA in patients with glioblastma undergoing treatment with first-line chemoradiotherapy

However, there are currently no published studies that have used a high sensitivity DNA detection assay to quantify cfDNA in patients with GBM. The ability to reliably detect and quantify cfDNA in GBM as a surrogate of tumor burden and disease activity would lead to significantly improved clinical care for …

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  • 19 Feb, 2024
  • 1 location
Investigation of the Effect of Branched Chain Amino Acids on Fat-Induced Insulin Resistance in Healthy Adults.

This protocol will determine whether excess BCAAs worsen free fatty acid-induced insulin resistance. Following a small scale dose-confirmation study, insulin sensitivity in response to low-dose lipid infusion will be compared across simultaneous administrations of the 3 BCAAs, leucine alone, valine alone, or control to better understand the mechanistic contribution of …

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  • 19 Feb, 2024
  • 1 location