Allergy Clinical Trials

Efficacy, Safety, and Tolerability Topical Nasal Spray in the Prevention of SARS-CoV-2 Infection in Healthcare Personnel

The purpose of this study is to assess the effectiveness, safety, and tolerability of GLS-1200 to prevent SARS-CoV-2 infection in healthcare personnel. GLS-1200 contains quinine diluted in saline (salt water). Pre-clinical studies have shown that quinine stimulates nasal cells to secrete compounds that may prevent growth of bacteria and reduce viruses …

(PREDICT) A Multi-Center Study in Patients Undergoing Anthracycline-Based Chemotherapy to Assess the Effectiveness of Using Biomarkers to Detect and Identify Cardiotoxicity and Describe Treatment

Biomarkers are chemical markers found in the blood and can be released in response to cardiac injury. Additional secondary objectives are to define the sensitivity and specificity of echocardiography for the detection of cardiotoxicity and determine the natural history of anthracycline cardiotoxicity in patients identified as high risk via biomarkers.

Determination of B-cell responsiveness to the incretin hormones GLP-1 and GIP in Cystic Fibrosis (PRIME)

The earliest changes involve variable postprandial hyperglycemia, occurring earlier than two-hours: 30-, 60-, and 90-minute glucose levels during an OGTT are frequently elevated and may provide a more sensitive method for detecting glucose intolerance than 2-hour values. Delayed and blunted insulin secretion is found during OGTT even in CF patients …

Pilot Study of EsoCheck Compared to Biopsies and Brush Cytology During Endoscopy for Evaluation of Eosinophilic Esophagitis

The aims of this study are to determine the feasibility and safety of EsoCheck compared with EGD and sensitivity and specificity of brush cytology and EsoCheck in a prospective cross-sectional pilot study of adult patients at the University of Pennsylvania with known EoE.

Medtronic Evaluation of Multi-Electrode Phased RF Technology in Persistent Atrial Fibrillation

The Phased RF System includes the GENius Multi Channel Radio Frequency Ablation Generator and three anatomically designed, multi-electrode catheters: Pulmonary Vein Ablation Catheter GOLD (PVAC GOLD) Multi-Array Septal Catheter (MASC) Multi-Array Ablation Catheter (MAAC) INCLUSION CRITERIA History of symptomatic persistent or long-standing persistent atrial fibrillation defined as: o Persistent AF: …

Using Natural Language Processing to Identify Depression in Patients with HIV

The purpose of this study is to develop algorithms that may help detect depressive symptoms in social media posts, specifically among men who have sex with men and who have HIV.

Cardiovascular function in leukemia patients: an observational prospective study

We will also examine whether these sensitive parameters of cardiac function identify patients who will develop cardiovascular events. This is a prospective, observational, single-center study.

Cancer detection rate of Abbreviated (Fast) Breast MRI (AB-MR) after negative Digitial Breast Tomosynthesis in Women status post Conservation Therapy (BCT)

Women treated for primary breast cancer who undergo breast conservation therapy face an increased risk of developing a second breast cancer in the ipsilateral and the contralateral breast. Although mammographic screening is recommended annually, the sensitivity of mammography is limited in these patients due to the post treatment changes from …

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