Efficacy, Safety, and Tolerability Topical Nasal Spray in the Prevention of SARS-CoV-2 Infection in Healthcare Personnel

The purpose of this study is to assess the effectiveness, safety, and tolerability of GLS-1200 to prevent SARS-CoV-2 infection in healthcare personnel. GLS-1200 contains quinine diluted in saline (salt water). Pre-clinical studies have shown that quinine stimulates nasal cells to secrete compounds that may prevent growth of bacteria and reduce viruses …

(PREDICT) A Multi-Center Study in Patients Undergoing Anthracycline-Based Chemotherapy to Assess the Effectiveness of Using Biomarkers to Detect and Identify Cardiotoxicity and Describe Treatment

Over the past 2 decades, there has been a significant increase in life span of patients with cancer so that now, there are more than 10 million cancer survivors in the U.S. [1]. There is a growing recognition that although survival has improved, many long-term side effects including cardiac complications …

Determination of B-cell responsiveness to the incretin hormones GLP-1 and GIP in Cystic Fibrosis (PRIME)

The mechanisms underlying cystic fibrosis related diabetes (CFRD) pathophysiology must be better defined if care for people with CFRD is to be optimized or if development of CFRD is to be interrupted. Detailed studies of insulin secretion in CF are required to achieve this goal since 1) subtle insulin secretion …

Pilot Study of EsoCheck Compared to Biopsies and Brush Cytology During Endoscopy for Evaluation of Eosinophilic Esophagitis

Eosinophilic esophagitis (EoE) is a chronic inflammatory condition of the esophagus that can lead to remodeling and stricture formation. To assess response to therapy, upper endoscopy (EGD) with biopsies is performed. This can lead to multiple EGDs, which are invasive and costly. There is currently a substantial unmet need for …

Medtronic Evaluation of Multi-Electrode Phased RF Technology in Persistent Atrial Fibrillation

The study is expected to be conducted at approximately 40 centers located in Europe, Canada and the United States to support US Food and Drug Administration (FDA) marketing application. A maximum of 350 subjects will be enrolled in the study to ensure 300 subjects can be evaluated for the primary …

Using Natural Language Processing to Identify Depression in Patients with HIV

The purpose of this study is to develop algorithms that may help detect depressive symptoms in social media posts, specifically among men who have sex with men and who have HIV.

Cardiovascular function in leukemia patients: an observational prospective study

In the last decade, both the incidence and the survival of acute leukemia has been increasing. Therefore, detection of associated illnesses is important. We have recently observed that patients with acute leukemia treated with anthracyclines develop a high rate of symptomatic heart failure. To avoid this life-threatening illness, early detection …

Cancer detection rate of Abbreviated (Fast) Breast MRI (AB-MR) after negative Digitial Breast Tomosynthesis in Women status post Conservation Therapy (BCT)

Women treated for primary breast cancer who undergo breast conservation therapy face an increased risk of developing a second breast cancer in the ipsilateral and the contralateral breast. Although mammographic screening is recommended annually, the sensitivity of mammography is limited in these patients due to the post treatment changes from …

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