Traumatic Brain Injury Clinical Trials

ESCAPE Room for Rehabilitation

This study aims to evaluate user experiences in commercial ESCAPE rooms to determine design opportunities for an ESCAPE room targeted for Rehabilitation after traumatic and non-traumatic brain injury. We will investigate older versus younger as well as healthy versus impaired user experiences in commercial ESCAPE room (survey) and 2) will …

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Transforming Research and Clinical Knowledge in Traumatic Brain Injury

Traumatic brain injury (TBI) is among the leading causes of death and disability worldwide with enormous social and economic impacts. The heterogeneity of TBI, combined with the lack of precise outcome measures, have been central to the discouraging results from numerous clinical trials.

Cerebrovascular reactivity assessed with functional near-infrared spectroscopy as a biomarker of traumatic microvascular injury after traumatic brain injury

Traumatic cerebrovascular injury (TCVI) is common after traumatic brain injury (TBI) and an attractive target for therapeutic intervention. We will longitudinally measure cerebrovascular reactivity (CVR) by functional near-infrared spectroscopy (fNIRS) in acute (3 days from injury), subacute, and chronic phases after TBI as a biomarker of TCVI as compared to …

Transforming Research and Clinical Knowledge in Traumatic Brain Injury: Biomarker Project

The goal of this study is to better understand that which contributes to the long-term recovery of people who have sustained a traumatic brain injury. To better understand an individual’s recovery following a head-injury, we will measure and examine the chemicals released in the brain and blood following the injury.

A Phase 2 Multi-center Randomized Double-Blind Placebo-Controlled Dose Range Finding Study to Evaluate the Safety Hemodynamic Effects and Efficacy of Intramuscular Injection of Human Placenta-Derived Cells (PDA-002) in Subjects who have Diabetic Foot Ulcer with Peripheral Arterial Disease

In the case of bilateral limb ulcers, the treated limb will be the limb that has the lowest qualifying TcPO2 value or ABI/TBI for inclusion. During the Treatment Period subjects will receive IM injections of PDA-002 on Study Days 1, 29 and 57 and will be evaluated on Study Days …

Transforming Research and Clinical Knowledge in Traumatic Brain Injury Epileptogenesis Project

TRACK-TBI EPI is an observational study of the TRACK-TBI longitudinal cohort. Subjects will be contacted 2-5 years after their index TBI for consent to a phone interview.