Multiple Sclerosis Clinical Trials
A listing of Multiple Sclerosis medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
Found 54 clinical trials
Estriol and Cognition in Multiple Sclerosis
The purpose of this study is to determine whether the combination of treatment with available MS therpies and estriol has an effect on cognitive function and disease activity and outcomes.
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- 19 Feb, 2024
- 1 location
A study to evaluate an oral medication, Siponimod (BAF312), in patients with Secondary Progressive Multiple Sclerosis
The main purpose of the study is to see how effective and safe BAF312 is compared to a Placebo in patients with Secondary Progressive MS. A placebo is a “pill” (capsule or tablet) with no medicine inside. A placebo is used to make sure that the changes you report are …
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- 19 Feb, 2024
- 1 location
Obsessive-compulsive disorder (OCD) Investigational Medication
The Center for the Treatment and Study of Anxiety is offering an investigational medication for people who have obsessive-compulsive disorder (OCD) and are currently taking an SRI medication for their OCD but still have unwanted symptoms.
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- 19 Feb, 2024
- 1 location
An Open-Label Phase 1 Study to Evaluate the Safety of ATA188 in Subjects with Progressive and Relapsing-Remitting Multiple Sclerosis
The purpose of the study is to determine the safety and tolerability of ATA188 in subjects with progressive forms of multiple sclerosis. Up to 42 male or female subjects with progressive forms of MS and 42 subjects with Relapsing-Remitting MS will be enrolled.
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- 19 Feb, 2024
- 1 location
Trial of Best Available Therapy versus Autologous Hematopoietic Stem Cell Transplant for Treatment-Resistant Relapsing Multiple Sclerosis
The purpose of this study is to compare efficacy and safety of Autologous Hematopoietic Stem Cell Transplant (AHSCT) to best available therapy (BAT) in relapsing MS. Best available therapy is referring to the best available medications that are used to treat MS. Patients who agree to participate in the experimental …
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- 19 Feb, 2024
- 1 location
North American Registry for Care and Research in MS - NARCRMS
NARCRMS is a national database that collects patient and physician-based information on MS and will bring together information and data collected in multiple registries and databases across the U.S. and Canada. We expect that data collected consistently over long periods of time, when carefully studied, will 1) produce new clues …
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- 19 Feb, 2024
- 1 location
Multicenter randomized double-blind parallel-group add-on superiority study to compare the efficacy and safety of ponesimod to placebo in subjects with active relapsing multiple sclerosis who are treated with dimethyl fumarate (Tecfidera )
This is a study to find out whether patients with active forms of Relapsing Multiple Sclerosis (RMS) who are treated with dimethyl fumarate (Tecfidera®) can be treated better by the addition of ponesimod (study drug). The purpose is also to evaluate the effect on disability and the safety of these …
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- 19 Feb, 2024
- 1 location
Effect of GLP-1 Agonist Therapy on Insulin Secretion in Adults with Pancreatic Insufficient Cystic Fibrosis and Abnormal Glucose Tolerance: a randomized open-label cross-over trial
Diabetes is a major co-morbidity in pancreatic insufficient cystic fibrosis (PI-CF) and associated with worse outcomes. While reduced -cell mass contributes to the insulin secretory defects that characterizes cystic fibrosis-related diabetes (CFRD), other modifiable determinants appear operative in the emergence and progression of abnormal glucose tolerance towards diabetes. Identifying interventions …
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- 19 Feb, 2024
- 1 location
Investigation of the Effect of Branched Chain Amino Acids on Fat-Induced Insulin Resistance in Healthy Adults.
Elevations in plasma levels of branched chain amino acids (BCAAs, comprising leucine, valine, and isoleucine), a large component of protein, are strongly associated with insulin resistance and type 2 diabetes, but mechanisms for this relationship are unclear. This protocol will determine whether excess BCAAs worsen free fatty acid-induced insulin resistance. …
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- 19 Feb, 2024
- 1 location