Cochlear Implant Speech in Noise Processing

  • STATUS
    Recruiting
  • End date
    Mar 31, 2028
  • participants needed
    150
  • sponsor
    Phillip Gander
Send
Updated on 31 March 2026
See if I qualify

Summary

The study will help us in understanding the neural mechanisms by which listeners with a cochlear implant detect speech in noisy environments. 123

Description

Despite the success of a cochlear implant (CI) for providing or improving hearing ability for people with severe hearing loss, everyday conversations in background noise are still the main clinical complaint. The goal of this study is to understand the neural mechanisms by which listeners with a CI detect speech in noisy environments, and to understand how these mechanisms differ across a variety of CI listeners, in order to determine what variables are most relevant for predicting successful outcome. Therefore the purpose of PET neuroimaging in this study is to find the brain regions that relate to speech in noise effort using PET during auditory stimulation on a single session across a variety of CI users with different device configurations. An age-matched typical hearing control group provides a baseline for comparison. PET neuroimaging will be performed using a radioactive form of water, O-15 (an investigational agent), that will be injected into the body to examine brain blood flow using a PET/CT scanner.

Details
Condition Hearing Loss, Adult-Onset, Speech Intelligibility, Hearing Loss, Extreme
Age 18years - 99years
Clinical Study IdentifierNCT06860152
SponsorPhillip Gander
Last Modified on31 March 2026

Eligibility

 Yes No Not Sure

Inclusion Criteria

Between 18 and 99 years of age
Have age typical hearing
Eligible for research under the Iowa Cochlear Implant Project VIII
Ability to understand and willingness to sign a written informed consent document

Exclusion Criteria

Medical history includes seizure disorder, head injury, neurologic, metabolic, cardiovascular disease, or previous cerebrovascular event (unless approved by PI)
Female self-reporting pregnancy. A urine pregnancy test will be performed prior to injection of the radiopharmaceutical
Currently taking medications which may affect cerebral blood flow (e.g., papaverine, ginkgo biloba, acetazolamide)
Uncontrolled intercurrent illness that would limit compliance with study requirements per investigator
Clear my responses
Read more

How to participate?

Step 1 Connect with a study center
Message sent successfully.
We have submitted the information you provided to the research team at the location you chose. For your records, we have sent a copy of the message to your email address.
If you would like to be informed of other studies that may be of interest to you, you may sign up for Patient Notification Service.
Sign up

Send a message

Enter your contact details to connect with study team

Email

View email

Phone

Phone country flag

View phone
Investigator Avatar

Primary Contact

First name*
Last name*
Email*
Phone number*
Preferred way of contact
Race
Ethnicity
Other language

Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider

Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer
Add a private note
  • abc Select a piece of text.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.