External Drainage of Thoracic Duct Lymph to Reduce Inflammatory Cytokines in Septic Shock Patients: A Pilot Trial with Concurrent Controls to Confirm Safety and Assess Preliminary Efficacy

  • STATUS
    Recruiting
  • participants needed
    40
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Updated on 19 February 2024

Summary

This is an interventional cohort study (n=10) that will involve external drainage of thoracic duct lymph in Surgical ICU patients with septic shock. The lymph drainage will continue for up to a maximum of 7 days and will be continued in those patients discharged from ICU back to the ward before that time. The lymph (and time matched blood) will be periodically sampled to detect changes in composition which will be correlated with changes in disease severity and outcomes, as well as patient physiology and biochemistry. This pilot study is not powered to detect changes in hospital/ICU stay, major complications or mortality. The primary endpoint of interest is the pro-inflammatory cytokine profile and concentrations in lymph and peripheral blood.

Details
Condition Septic Shock
Age 99years or below
Clinical Study IdentifierTBD
Last Modified on19 February 2024

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