Phase 1 Study of Convalescent Plasma for Severely ill Mechanically Ventilated Participants with COVID-19 Caused by SARS-CoV-2

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    Enrolling By Invitation
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Updated on 19 February 2024

Summary

Only patients admitted to the hospital and on a ventilator for treatment of COVID-19 are eligible to participate.
 
The purpose of this study is to develop a possible new treatment for COVID-19 disease which uses antibodies against this virus. Antibodies are natural proteins made by the body that attack viruses and other germs. These antibodies are found in plasma, the yellow, clear part of the blood. There have been other studies using plasma to treat other types of viruses that showed some positive results.

Description

We have collected plasma from people who had COVID-19 infection (convalescent) and that we expect to have high levels of the antibodies against this virus. In this study, we will transfuse this high antibody plasma or convalescent plasma into people currently infected with the virus that caused COVID-19 disease. 

We want to see if the plasma with antibodies helps people with COVID-19 improve. The plasma is given in addition to standard medications and treatment for your infection. 

The purpose of this study is to see if this plasma can be safely used in humans with COVID-19 and to see if it can improve patients’ health when they are sick with COVID-19.

FAQ


Details
Condition Coronavirus,covid19,COVID-19,COVID 19
Age 18years - 100years
Clinical Study IdentifierTX6424
Last Modified on19 February 2024

Eligibility

If you need help finding a study or have any questions, please contact us at psom-ocr@pobox.upenn.edu

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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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