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Identification of neoantigen-specific T cell responses in cancer patients within the Penn Medicine BioBank

Identification of neoantigen-specific T cell responses in cancer patients within the Penn Medicine BioBank

Enrolling By Invitation
18-90 years
All
Phase N/A
The main purpose of this study is to identify immune fighting cells known as T cells that recognize proteins expressed by cancer cells. The results of this study will be used to develop new treatments for cancer patients using the body’s immune system. The study involves providing a blood sample to be used in the laboratory for immune system research at the University of Pennsylvania. Your cells will be collected and purified by members of the Vonderheide lab. Your immune cells known as white blood cells will be analyzed to determine your Human Leukocyte Antigen (HLA) type. HLA is a unique genetic marker or “fingerprint” on white blood cells that are important for how your immune system fights infections and cancer. Your white blood cells will then be used in the laboratory to study how the cells of the immune system recognize and kill cancer cells. No experimental treatments or procedures will be performed on you. These research results will not be of direct benefit to you, however, the results may provide important benefits to patients with cancer in the future. With this in mind, you are being asked to serve as a volunteer to donate white blood cells for this research study.
Study details
    cancer

TX6312

19 February 2024

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