A Phase II Study of the Anti-GITR Agonist INCAGN01876 and the PD-1 Inhibitor INCMGA00012 in Combination with Stereotactic Radiosurgery in Recurrent Glioblastoma

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    Recruiting
  • participants needed
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Updated on 19 February 2024

Summary

The following protocol is a phase II study of the combination of the GITR agonist monoclonal antibody INCAGN01876, the anti-PD1 monoclonal antibody INCMGA00012, and SRS for recurrent GBM. We hypothesize that the proposed regimen will be safe and stimulate a robust anti-tumor immune response and result in improved tumor responses. The purpose of this protocol is to determine the efficacy of the combination of INCMGA00012, INCAGN01876, and SRS in recurrent GBM, as measured by the overall objective response rate (ORR). INCAGN01876 (anti-GITR) 300mg will be administered IV every 2 weeks until disease progression, unacceptable toxicity, or 2 years, whichever occurs first. INCMGA00012 (anti-PD1) 500mg will be administered IV every 4 weeks until disease progression, unacceptable toxicity, or 2 years, whichever occurs first.

Details
Condition Medical Research
Age 99years or below
Clinical Study IdentifierTBD
Last Modified on19 February 2024

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